[Genetic dimorphism in beta-aminoisobutyric acid excretion in patients with atherosclerosis of the coronary artery and in groups at risk for atherosclerosis in the Lithuanian population].

Frequency of genetic variants of excretion of beta-aminoisobutyric acid (BAIB) in the urea was examined in patients suffering from atherosclerosis of coronary arteries and in risk group for atherosclerosis: children frequently suffering from respiratory viral infection, children with insulin-dependent diabetes mellitus (IDDM) and in adults suffering from IDDM and non-insulin-dependent diabetes mellitus. With the aim to determine whether excretion of BAIB could be related with CMV persistence of with proteolytic activity of blood serum the IgG class antibodies against CMV and level of alpha 1-proteinase inhibitor (alpha 1-PI) in blood serum was tested also. Frequency of high excretors of BAIB was found significantly more often (P < 0.

[Interrelation of genetic dimorphism of ear wax and the level of apolipoproteins with atherogenesis and longevity in the Lithuanian population].

Genetic dimorphism of the cerumen was studied in a random sample from the Lithuanian population (N = 253), among the patients with the most atherosclerotic risk, from different age groups (N = 276) and in a cohort of long-living (N = 117). Simultaneously, the levels of apolipoprotein (apo- A-1, B, E) were determined in blood sera of the males-donors, long-living and elderly individuals depending on the phenotypes for ear wax consistency. The prevalence of frequency of the w gene for humid cerumen in children suffering from the insulin-dependent diabetes mellitus was found as compared with populational sample--0.

[Atherogenesis and serum levels of apolipoprotein E].

Serum apolipoprotein (apo) E levels and their relationship with age were examined in different age groups of healthy individuals of both sexes in a Lithuanian population. The serum concentrations of apo E in patients after coronary bypass were measured and patients suffered from diabetes mellitus were also examined. The mean levels of apo E were found to be higher in healthy males than those in healthy females only in young age.

[Plasma apolipoproteins B and AI in healthy individuals and patients with coronary atherosclerosis in a male population from Lithuania].

The paper discusses the results from a study into apolipoproteins B (apo-B) and AI (apo-AI) and apoB/apo-AI ratios in the blood of 188 healthy donors and 122 male patients with coronary atherosclerosis. Atherosclerotic lesions were coronary angiographically documented. The study was performed (in two age groups of patients: 1) those under 45 years and 2) those over 45 years.

[Atherosclerosis of the coronary arteries and the blood group in the population of Lithuania].

Data are reported on the relation between atherosclerosis of the coronary arteries and blood group. Examined were 291 patients in whom involvement of the coronary arteries was verified by means of coronarography and aortocoronary shunting. It was established that the group B blood was distinctly more frequent and group O blood was distinctly less frequently observed in male patients under 45 years.

[Study of serum levels of alpha 1-antitrypsin and alpha macroglobulins in children with glomerulonephritis].

To define the clinico-pathogenetic importance of alpha 1-inhibitor of proteinases and alpha 2-macroglobulin of the blood in children with glomerulonephritis, a study was made of the phenotype of alpha 1-inhibitor of proteinases and its concentration in the blood serum of 156 patients with different clinical forms of glomerulonephritis. Overall 1290 practically healthy children were examined as control. The patients suffering from glomerulonephritis did not demonstrate phenotypes responsible for acute deficiency of alpha 1-inhibitor of proteinases (PISS, PISZ).

[Phenotypes of the alpha-1 proteinase inhibitor in septic diseases and leukemia in children].

Employment of isoelectrofocussing techniques for the determination of proteinase alpha 1-inhibitor (p alpha 1i) phenotypes helped detect original rare phenotypes. Their accurate identification should be performed with a set of standard sera. The findings of studies on the number of p alpha 1i by Mancini's immunoprecipitation test are analyzed, as are the data of phenotype studies by p alpha 1i isoelectrofocussing in children suffering from acute leukemia and sepsis.