[Experience with dupilumab in the treatment of chronic rhinosinusitis with nasal polyps].

Unlabelled: Chronic rhinosinusitis (CRS) with nasal polyps is the most severe form of inflammatory diseases of the paranasal sinuses, especially in combination with comorbid asthma. A new avenue for the personalized treatment of severe forms of eosinophilic inflammation are biologics based on humanized monoclonal antibodies.

Objective: To study the effectiveness of targeted therapy in patients with CRS with nasal polyps and comorbid asthma.

[Peculiarities of fungal and bacterial microorganisms persistence in the structure of fungal balls of paranasal sinuses].

Objective: To compare the data of pathomorphological and microbiological examination of fungal balls removed at paranasal sinuses endoscopic surgery.

Material And Methods: A total of 148 samples were obtained from patients histologically diagnosed with fungal balls. Microscopic evaluation of the specimens stained according to the Gram method, Gomori-Grocott method and PAS-reaction method, revealed phase changes in the fungal balls conditioned by their different life cycles: the areas of young, mature and degenerating mycelium were detected.

[Children's rhinosinusitis orbital complications].

The number of cases of children's sinogenic orbital complications does not reduce in spite of the advanced methods of paranasal sinuses visualization, wide use of antibacterial therapy against sinusitis, and preventive vaccination against pneumococcal disease. Orbital complications are more common with children than with adults, the basic reason of their development being ethmoiditis. The prevailing classification of orbital complications proposed by J.

[COVID-19 associated sino-orbital mucormycosis].

Objective: To analyze the dynamics of symptoms in patients with COVID-19 associated sino-orbital mucormycosis.

Material And Methods: We describe a series of 13 patients with COVID-19 associated sino-orbital mucormycosis aged 43 to 80 years diagnosed from August to October 2021. All of the patients had a severe disease and required noninvasive ventilation or intubation and administration of dexamethasone.

[Presbyvestibulopathy in clinical practice.].

With increasing life expectancy, there is an increase in the number of patients with symptoms caused by aging of the vestibular system - presbyvestibulopathy. Presbyvestibulopathy is based on degenerative processes in various parts of the vestibular analyzer - from the semicircular canals and otolithic receptors to the conduction tracts and vestibular nuclei. When examining such patients, it is necessary to take into account the multiplicity of damage to sensory systems in the elderly (impaired balance, vision, cognitive functions).

[Small salivary glands in the paratonsillar space in children].

Was to study the changes in the small salivary glands in chronic tonsillitis and paratonsillar abscess in children. A histological examination of the palatine tonsils of 22 children aged 5 to 14 years old who had a paratonsillar abscess and 18 children suffering from chronic tonsillitis was carried out. Fragments of small salivary glands, located both superficially, in the mucous membrane between the stratified squamous non-keratinizing epithelium and the lymphoid tissue of the palatine tonsils, and between the muscles of the amygdala were found in 42 of the 80 (52.

[Proinflammatory cytokine content in the saliva of children suffering from chronic tonsillitis].

Introduction: We have examined 92 children aged between 6 and 15, suffering from chronic tonsillitis (CT). Tumor necrosis factor (TNF-α) and interleukin 1β and 6 (IL-1β and IL-6) contents have been defined in saliva. The control set comprised 17 healthy children.

[The influence of corticosteroids on the frequency of vestibular crises].

The objective of the present study was to elucidate the dynamics of the hormonal status of the adrenal glands in the patients suffering from Menière's disease in its different clinical forms. We examined a total of 26 patients at the age from 29 to 47 years presenting with this condition. All the patients were divided into two groups depending on the character of the disease.

[The significance of antistreptolysin O characteristics for the determination of indications for tonsillectomy in the children].

The objective of the present work was to evaluate the diagnostic significance of the measurement of the antistreptolysin O (ASLO) titers in the children presenting with chronic tonsillitis for determining the indications for tonsillectomy. The study included 54 patients at the age varying from 4 to 17 years who had undergone bilateral tonsillectomy for the treatment of chronic tonsillitis. The diagnosis was confirmed by the results of the histological study of the removed amygdalae.

[Acute and chronic frontitis: the current view of the problem].

The number of patients presenting with the inflammatory diseases of paranasal sinuses remains rather high both in this country and all over the world despite the development of new methods for diagnostics and treatment of this pathology and their extensive application in the clinical practice. The present paper offers a systematic review of the literature concerned with diagnostics of acute and chronic diseases of frontal sinuses published during the period from 2005 to 2011. The analysis of these publications has demonstrated that these diseases still constitute a challenging problem for otorhinolaryngology despite the improvement of technologies for their diagnostics and management.

[Significance of local pain syndrome in patients with frontitis].

The diagnostic value of local pain symptom as a key sign of frontitis is currently regarded as rather low. It occurred only in 69 (14%) of the 487 patients with this disease examined in the present study. Patients presenting with ambiguous symptoms of uncomplicated unilateral frontitis were studied by rheofrontography using coefficient of asymmetry as a diagnostic criterion (its value in excess of 24% indicates the presence of exudate in the sinus cavity.