Publications by authors named "Stacy Ruse"

Article Synopsis
  • Assessment of functional capacity is crucial for understanding how cognitive impairment in schizophrenia affects treatment responses, with existing methods mainly relying on paper simulations.
  • A new tool, the Virtual Reality Functional Capacity Assessment Tool (VRFCAT), was tested on 54 healthy individuals and 51 people with schizophrenia, measuring completion times and errors during a simulated shopping trip.
  • Results showed that individuals with schizophrenia performed worse than healthy controls in most measures, suggesting that computerized assessments could be beneficial, though further research is needed.
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Cognitive functioning can be assessed with performance-based assessments such as neuropsychological tests and with interview-based assessments. Both assessment methods have the potential to assess whether treatments for schizophrenia improve clinically relevant aspects of cognitive impairment. However, little is known about the reliability, validity and treatment responsiveness of interview-based measures, especially in the context of clinical trials.

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Cognitive impairments affect the majority of patients with schizophrenia and these impairments predict poor long term psychosocial outcomes.  Treatment studies aimed at cognitive impairment in patients with schizophrenia not only require demonstration of improvements on cognitive tests, but also evidence that any cognitive changes lead to clinically meaningful improvements.  Measures of "functional capacity" index the extent to which individuals have the potential to perform skills required for real world functioning.

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