Publications by authors named "Stacy L Mosier"
Article Synopsis
- The study aimed to validate next-generation sequencing (NGS) technology for clinical use and determine the optimal read depth needed for accurate diagnosis of gene mutations.
- Researchers validated specific genes (KRAS, BRAF, and EGFR) using the Ion Torrent Personal Genome Machine and developed a statistical model to identify the necessary read depth based on tumor cellularity.
- Results indicated that while NGS is effective for detecting gene mutations, employing multiple bioinformatic pipelines is crucial to avoid false results, highlighting the importance of addressing potential artifacts in the data.
Lung cancer is the leading cause of cancer deaths in the United States, surpassing breast cancer as the primary cause of cancer-related mortality in women. The goal of the present study was to identify early molecular changes in the lung induced by exposure to tobacco smoke and thus identify potential targets for chemoprevention. Female A/J mice were exposed to either tobacco smoke or HEPA-filtered air via a whole-body exposure chamber (6 h/d, 5 d/wk for 3, 8, and 20 weeks).
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