Publications by authors named "Stacy L De Florencio"
Article Synopsis
- The study investigates the role of yolk-sac-derived microglia in Alzheimer's disease (AD), focusing on the gene ADGRG1 and its impact on microglial protective responses.
- Microglial deficiency of ADGRG1 was shown to increase amyloid plaque buildup, worsen brain pathology, and speed up cognitive decline in mouse models.
- The findings suggest that targeting microglial functioning, particularly through ADGRG1, could lead to new treatments to slow down the progression of Alzheimer's disease.
