Publications by authors named "Stacy J Steinmetz"
Article Synopsis
- Morphine is effective for pain relief in horses, but intravenous (IV) use can cause unwanted side effects like neuroexcitation and gastrointestinal issues.
- Oral administration of morphine yields similar pain-relief potential through the metabolite M6G without the negative effects of IV administration.
- The study found that oral morphine doses provided effective pain relief comparable to IV morphine while causing less excitation and gastrointestinal disturbances, indicating the need for further research.
Article Synopsis
- This study investigates the effects of a transdermal buprenorphine solution on horses, comparing its pharmacokinetics and antinociceptive properties with those of an intravenous (IV) injection, hypothesizing that transdermal application would yield more stable blood levels and fewer side effects.
- Eight horses aged 6-12 were given incremental doses of the transdermal solution along with a single IV dose, with blood concentrations measured using advanced chromatography techniques, while various health indicators like heart rate and temperature were recorded to evaluate the drug’s effects.
- Results showed that transdermal buprenorphine had low systemic concentrations (only 11% bioavailability) and provided inconsistent pain
Background: Clenbuterol, a beta2-adrenergic receptor agonist, is used therapeutically to treat respiratory conditions in the horse. However, by virtue of its mechanism of action it has been suggested that clenbuterol may also have repartitioning affects in horses and as such the potential to affect performance. Clenbuterol decreases the percent fat and increases fat-free mass following high dose administration in combination with intense exercise in horses.
View Article and Find Full Text PDF