Publications by authors named "Stacy Cook"
Article Synopsis
- Laryngeal injury from intubation can cause issues with voice and swallowing, and this study aimed to explore the effects of intubation on laryngeal mechanics, inflammation, and the local microbiome changes.
- The researchers simulated intubation injuries in pigs and tested endotracheal tubes infused with different drugs, examining the tissue response, stiffness, and inflammation at various time intervals.
- Results showed that the roxadustat tubes increased vocal fold stiffness but maintained severe inflammation, while valacyclovir tubes decreased inflammation and ulcers over time, highlighting differing therapeutic effects on laryngeal recovery.
Article Synopsis
- - Corticosteroid-eluting endotracheal tubes (ETTs) with polycaprolactone (PCL) fibers were tested in swine to prevent airway scarring and maintain airway openness after laryngotracheal injury.
- - The study compared two types of ETTs (regular vs. dexamethasone-PCL coated) in injured and native airways, evaluating tissue stiffness and histological changes over 14 days post-injury.
- - Results indicated that dexamethasone-coated ETTs significantly reduced tissue stiffness and collagen buildup compared to regular ETTs, suggesting their effectiveness in mitigating intubation-related scarring.
Effect of continuous local dexamethasone on tissue biomechanics and histology after inhalational burn in a preclinical model.
Laryngoscope Investig Otolaryngol
August 2023
Objective: Inhalational burns frequently lead to dysphonia and airway stenosis. We hypothesize local dexamethasone delivery via a novel drug-eluting electrospun polymer-mesh endotracheal tube (ETT) reduces biomechanical and histologic changes in the vocal folds in inhalational burn.
Methods: Dexamethasone-loaded polymer mesh was electrospun onto ETTs trimmed to transglottic endolaryngeal segments and secured in nine Yorkshire Crossbreed swine with directed 150°C inhalation burns.
Article Synopsis
- The study aims to measure the forces exerted during laryngoscopy across different expertise levels (students, residents, staff) and varying airway difficulties using force gauges attached to a mannequin.
- Results show that as airway difficulty increased, all groups applied more force on the teeth and tongue base, with students exerting the most force overall.
- The findings indicate that the measurement of these forces could serve as valuable indicators for assessing training and competency in laryngoscopy techniques.
Introduction: The transition to medical school is a particularly challenging time for new students as they are faced with significant academic responsibilities. Moreover, for many students at the Uniformed Services University they are adjusting to being on active duty in the military. Mentoring has been considered a way to help with the transition and professional development.
View Article and Find Full Text PDFThis article explores the legal implications of pay for performance programs from the perspective of healthcare providers. The author provides an informative background on the emergence of pay for performance programs and examines the structure and operation of these programs. She then explores the liability issues of health plans and managed care organizations and delves into evidentiary issues related to pay for performance information.
View Article and Find Full Text PDFAn investigation of the critical factors effecting the resolution of SR695 from efavirenz in the assay of efavirenz by reversed-phase HPLC was performed. This study was implemented to address the inability of a subset of the Zorbax SB-CN columns used in this method to adequately perform this separation, which were otherwise indistinguishable from columns of this type that could. In this study, column temperature, detector time-constant, pre-gradient isocratic hold-time, pre-column mixing volume, column, and HPLC type were considered.
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