Effects of chemotherapy on skin and hair.

Skin and hair are both notable and noticeable accessory targets of chemotherapy and can become a point of discussion when your patient asks, "Is this problem happening because of my chemo?" This article will attempt to assist physicians in recognizing and answering this question.

Ehlers–Danlos syndrome and anorexia nervosa: a dangerous combination?

A 16-year-old boy with anorexia nervosa and Ehlers–Danlos syndrome presented with spontaneous pneumomediastinum and bradycardia.Although prior occurrences of pneumomediastinum and visceral perforations have been reported in adolescents with isolated anorexia nervosa or Ehlers–Danlos syndrome, to our knowledge this is the first instance to be noted in a patient with both conditions.We explore several possibilities regarding the etiology of his mediastinal air, but ultimately conclude that it was the existence of Ehlers–Danlos syndrome in the presence of anorexia nervosa that led to the development of this dangerous condition.

Uptake and trafficking of mildly oxidized LDL and acetylated LDL in THP-1 cells does not explain the differences in lysosomal metabolism of these two lipoproteins.

Foam cells in the atherosclerotic lesion have substantial cholesterol stores within large, swollen lysosomes. This feature is mimicked by incubating THP-1 macrophages with mildly oxidized low density lipoprotein (LDL). Incubation of THP-1 cells with acetylated LDL produces cytoplasmic cholesteryl ester accumulation rather than lysosomal storage.