The PP2A-B56 Binding Site LxxIxE Contributes to Asp-Mediated Spindle Pole Stability.

The organization of microtubules into a mitotic spindle is critical for animal cell proliferation and involves the cooperation of hundreds of proteins whose molecular roles and regulation are not fully understood. The protein product of the Drosophila gene abnormal spindle, Asp, is a microtubule-associated protein required for correct mitotic spindle formation. To better understand the contribution of Asp to microtubule organization during spindle formation, we reverse-engineered flies to express a version of Asp (Asp), predicted to have lost its ability to bind the phosphatase trimer PP2A-B56.

Adaptive Just-in-Time Intervention to Reduce Everyday Stress Responses: Protocol for a Randomized Controlled Trial.

Background: Personalized approaches to behavior change to improve mental and physical health outcomes are needed. Reducing the intensity, duration, and frequency of stress responses is a mechanism for interventions to improve health behaviors. We developed an ambulatory, dynamic stress measurement approach that can identify personalized stress responses in the moments and contexts in which they occur; we propose that intervening in these stress responses as they arise (ie, just in time; JIT) will result in positive impacts on health behaviors.

Social Media Activities and Affective Well-being in the Daily Life of Emerging Adults.

Previous work suggests that some social media (SM) activities may have detrimental effects on users' affective well-being, whereas other activities can be more adaptive. SM use is typically assessed with global or retrospective measures; it remains unclear how its relation with affect may play out in real-time and in regard to specific SM activities, as opposed to general SM use. The current study investigated the association between specific SM activities (posting, viewing others' posts, liking/commenting, checking replies to one's own posts, direct messaging) and concurrent positive and negative affect in a sample of  = 349 18-year-old emerging adults.

Soil data recency: The foundation for harmonizing soil data across time.

Sustainable soil resource management depends on reliable soil information, often derived from 'legacy soil data' or a combination of old and new soil data. However, the task of harmonizing soil data collected at different times remains a largely unexplored in the literature. Addressing this challenge requires incorporating the temporal dimension into mathematical and statistical models for spatio-temporal soil studies.

Exposure to neighborhood violence, and laboratory-based and ambulatory cognitive task performance in adulthood.

Objective: Exposure to neighborhood violence may have negative implications for adults' cognitive functioning, but the ecological sensitivity of these effects has yet to be determined. We first evaluated the link between exposure to neighborhood violence and two latent constructs of cognitive function that incorporated laboratory-based and ambulatory, smartphone-based, cognitive assessments. Second, we examined whether the effect of exposure to violence was stronger for ambulatory assessments compared to in-lab assessments.

Improving the Transition of Older Adults into Residential Aged Care: A Scoping Review.

Objectives: The transition into residential aged care (RAC) is often associated with loss, grief, isolation and loneliness. This scoping review aimed to identify quantitative research which focused on reducing the negative effects associated with transition, thereby improving the transition experience.

Methods: A scoping review, which concentrated on quantitative research, was conducted.

Epigenetic Age Acceleration and Chronological Age: Associations With Cognitive Performance in Daily Life.

DNA methylation-derived epigenetic clocks offer the opportunity to examine aspects of age acceleration (ie, the difference between an individual's biological age and chronological age), which vary among individuals and may better account for age-related changes in cognitive function than chronological age. Leveraging existing ambulatory cognitive assessments in daily life from a genetically diverse sample of 142 adults in midlife, we examined associations between 5 measures of epigenetic age acceleration and performance on tasks of processing speed and working memory. Covarying for chronological age, we used multilevel models to examine associations of epigenetic age acceleration (Horvath 1, Horvath 2, Hannum, PhenoAge, and GrimAge clocks) with both average level and variability of cognitive performance.

Examining the Bidirectional Nature of Loneliness and Anxiety Among Older Adults in Daily Life.

Objectives: Loneliness in later life increases the risk for adverse health outcomes; however, less is known about how loneliness is maintained. Anxiety may play an important role in maintaining loneliness, but little is known about how this connection plays out over time in daily life. This study thus focused on the within-person associations between momentary loneliness and anxiety among older adults.

The relationship between loneliness and the experiences of everyday stress and stressor-related emotion.

Loneliness influences how people experience and respond to stressors, which may account for its role as a risk factor for morbidity and mortality. The present study was motivated by emerging evidence that affective responses to minor daily events have long-term implications for health and well-being. Specifically, we evaluated how individual differences in loneliness relate to the frequency of everyday stressors and stressor-related negative emotions.

Subjective cognition and memory lapses in the daily lives of breast cancer survivors: Examining associations with objective cognitive performance, fatigue, and depressed mood.

Objective: Subjective reports of cancer-related cognitive impairment often far exceed that documented using in-person neuropsychological assessment. This study evaluated whether subjective cognition was associated with real-time objective cognitive performance in daily life versus performance on an in-person neuropsychological battery, as well as fatigue and depressed mood.

Methods: Participants were 47 women (M age = 53.

Computing Components of Everyday Stress Responses: Exploring Conceptual Challenges and New Opportunities.

Repeated assessments in everyday life enables collecting ecologically valid data on dynamic, within-persons processes. These methods have widespread utility and application and have been extensively used for the study of stressors and stress responses. Enhanced conceptual sophistication of characterizing intraindividual stress responses in everyday life would help advance the field.

Daily Social Interactions and Momentary Loneliness: The Role of Trait Loneliness and Neuroticism.

Objectives: Loneliness has been linked to poor mental and physical health outcomes in later life. Little is known about how daily social interactions relate to older adults' everyday experiences of loneliness. This study examined the dynamic associations between social interactions and the momentary feelings of loneliness in older adults' daily lives.

The where and when of COVID-19: Using ecological and Twitter-based assessments to examine impacts in a temporal and community context.

In March 2020, residents of the Bronx, New York experienced one of the first significant community COVID-19 outbreaks in the United States. Focusing on intensive longitudinal data from 78 Bronx-based older adults, we used a multi-method approach to (1) examine 2019 to early pandemic (February-June 2020) changes in momentary psychological well-being of Einstein Aging Study (EAS) participants and (2) to contextualize these changes with community distress scores collected from public Twitter posts posted in Bronx County. We found increases in mean loneliness from 2019 to 2020; and participants that were higher in neuroticism had greater increases in thought unpleasantness and feeling depressed.

The Association Between Loneliness and Inflammation: Findings From an Older Adult Sample.

Loneliness has been linked to poor mental and physical health outcomes. Past research suggests that inflammation is a potential pathway linking loneliness and health, but little is known about how loneliness assessed in daily life links with inflammation, or about linkages between loneliness and inflammation among older adults specifically. As part of a larger investigation, we examined the cross-sectional associations between loneliness and a panel of both basal and LPS-stimulated inflammatory markers.

Daily social interactions related to daily performance on mobile cognitive tests among older adults.

The lack of social contact or good social relationships has been linked with cognitive decline and higher risk for Alzheimer's disease and related dementias. One important but unexamined question is how daily social interactions relate to older adults' cognitive function in daily life. The present study examined how changes in daily social interactions related to fluctuations in older adults' performance on mobile cognitive tests from day to day.

Stressor anticipation and subsequent affective well-being: A link potentially explained by perseverative cognitions.

Anticipatory stress can prospectively and negatively influence diverse outcomes, including cognitive performance and emotional well-being. It has been suggested that perseverative cognitions (e.g.

Evidence that polyploidy in esophageal adenocarcinoma originates from mitotic slippage caused by defective chromosome attachments.

Polyploidy is present in many cancer types and is increasingly recognized as an important factor in promoting chromosomal instability, genome evolution, and heterogeneity in cancer cells. However, the mechanisms that trigger polyploidy in cancer cells are largely unknown. In this study, we investigated the origin of polyploidy in esophageal adenocarcinoma (EAC), a highly heterogenous cancer, using a combination of genomics and cell biology approaches in EAC cell lines, organoids, and tumors.

Does Chronic Stress Moderate Age Differences in Emotional Well-Being? Testing Predictions of Strength and Vulnerability Integration.

Objectives: The Strength and Vulnerability Integration (SAVI) theory posits boundary conditions, such as chronic stress, which place constraints on positive emotional aging. We examine SAVI's prediction that higher levels of chronic stress will attenuate favorable age gradients for multiple indices of well-being.

Methods: We used cross-sectional data from a diverse systematic probability sample of adults (n = 260, ages 25-65).