Screening and Preventative Strategies for Patients at High Risk for Breast Cancer.

Purpose: Current US guidelines recommend more intensive breast cancer screening and preventive strategies for patients at more than 20% lifetime risk for breast and ovarian cancer (high risk for breast and ovarian cancer [HRBOC]). Guidelines recommend that yearly mammograms alternating with magnetic resonance imaging (MRI) screening should be considered as early as 30 years old. Furthermore, mutation carriers should consider bilateral mastectomy and bilateral oophorectomy after age 35.