Publications by authors named "Sruthi Jayaraman"
Neurobiol Aging
June 2020
Article Synopsis
- A hexanucleotide repeat expansion in the C9orf72 gene is linked to familial and some sporadic cases of ALS and frontotemporal dementia.
- Inducible pluripotent stem cells from C9orf72+ ALS patients show that while their neuronal progenitor cells can differentiate into neurons, these C9+ neurons re-express cell cycle proteins and exhibit signs of aging or senescence after 12 weeks.
- The study indicates that C9+ neurons produce high levels of specific inflammatory molecules and reactive oxygen species, which may contribute to neuronal dysfunction in ALS and frontotemporal dementia.
