Publications by Sriya T Jonnakuti

Publications by authors named "Sriya T Jonnakuti"

Page 1 of 1

Hallmarks of CD8 T cell dysfunction are established within hours of tumor antigen encounter before cell division.

Michael W Rudloff Paul Zumbo Natalie R Favret Jessica J Roetman Carlos R Detrés Román Sriya T Jonnakuti

Nat Immunol

September 2023

Tumor-specific CD8+ T cells (TST) in patients with cancer are dysfunctional and unable to halt cancer progression. TST dysfunction, also known as exhaustion, is thought to be driven by chronic T cell antigen receptor (TCR) stimulation over days to weeks. However, we know little about the interplay between CD8 T cell function, cell division and epigenetic remodeling within hours of activation.

View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_session3jnobda35sptqiuh65sf7j6aram88s2l): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once