Publications by authors named "Srividhya V Iyer"
Article Synopsis
- - In Neurospora crassa, researchers studied progeny from crosses between normal strains and those with translocations, discovering that these crosses can produce offspring with a duplicated chromosome segment (Dp) that disrupts several genes and creates novel reading frames.
- - Specifically, a translocation disrupting the eat-3 gene was analyzed due to its relevance to a similar gene in another species (Podospora anserine), which was known to affect mutation rates; however, the study indicated that eat-3 is likely crucial for development in Neurospora.
- - Despite common difficulties in obtaining viable offspring from certain duplications, the use of molecular probes allowed the identification of some viable progeny, suggesting that the usual sterility in duplication
The Neurospora crassa fmf-1 mutation exerts an unusual 'perithecium-dominant' developmental arrest; fmf-1 x fmf-1+ cross becomes arrested in perithecial development regardless of whether the mutant participates in the cross as the male or female parent. We localized fmf-1 to the LG IL genome segment between the centromere-proximal breakpoint of the chromosome segment duplication Dp(IL)39311 and the centromere. By mapping crossovers with respect to RFLP markers in this region we further localized fmf-1 to an approximately 34-kb-genome segment.
View Article and Find Full Text PDFStudies on Neurospora chromosome segment duplications (Dps) performed since the publication of Perkins's comprehensive review in 1997 form the focus of this article. We present a brief summary of Perkins's seminal work on chromosome rearrangements, specifically, the identification of insertional and quasiterminal translocations that can segregate Dp progeny when crossed with normal sequence strains (i.e.
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