Visual object detection biases escape trajectories following acoustic startle in larval zebrafish.

In this study, we investigated whether the larval zebrafish is sensitive to the presence of obstacles in its environment. Zebrafish execute fast escape swims when in danger of predation. We posited that collisions with solid objects during escape would be maladaptive to the fish, and therefore, the direction of escape swims should be informed by the locations of barriers.

High-throughput screening for selective appetite modulators: A multibehavioral and translational drug discovery strategy.

How appetite is modulated by physiological, contextual, or pharmacological influence is still unclear. Specifically, the discovery of appetite modulators is compromised by the abundance of side effects that usually limit in vivo drug action. We set out to identify neuroactive drugs that trigger only their intended single behavioral change, which would provide great therapeutic advantages.