Publications by authors named "Srisamang P"
Background: Quantifying the excess mortality attributable to antimicrobial-resistant (AMR) bacterial infections is important for assessing the potential benefit of preventive interventions and for prioritization of resources. However, there are few data from low- and middle-income countries.
Methods: We conducted a 2-year prospective surveillance study to estimate the excess mortality attributable to AMR infections for all types of hospital-acquired infection (HAI), and included bacterial species that were both locally relevant and included in the World Health Organization priority list.
Objectives: The magnitude of impact caused by low blood culture utilization on estimates of the proportions and incidence rates of antimicrobial-resistant (AMR) bacterial infections is largely unknown.
Methods: We used routine electronic databases of microbiology, hospital admission and drug prescription at Sunpasitthiprasong Hospital, Ubon Ratchathani, Thailand, from 2011 to 2015, and bootstrap simulations.
Results: The proportions of Escherichia coli and Klebsiella pneumoniae bacteraemias caused by 3rd generation cephalosporin resistant isolates (3GCREC and 3GCRKP) were estimated to increase by 13 and 24 percentage points (from 44% to 57% and from 51% to 75%), respectively, if blood culture utilization rate was reduced from 82 to 26 blood culture specimens per 1,000 patient-days.
Background: Multi-modal interventions are effective in increasing hand hygiene (HH) compliance among healthcare workers, but it is not known whether such interventions are cost-effective outside high-income countries.
Aim: To evaluate the cost-effectiveness of multi-modal hospital interventions to improve HH compliance in a middle-income country.
Methods: Using a conservative approach, a model was developed to determine whether reductions in meticillin-resistant Staphylococcus aureus bloodstream infections (MRSA-BSIs) alone would make HH interventions cost-effective in intensive care units (ICUs).
Article Synopsis
- Severe septic patients in northeast Thailand face significant mortality rates, particularly with severe staphylococcal infections, where 28-day death rates reached 20%.
- Diabetes was identified as the most common underlying health issue, and while appropriate treatments were given to many patients, only a small percentage received care in an intensive care unit.
- The study found that factors such as coagulopathy and respiratory failure at the time of admission were linked to increased mortality, and plasma IL-8 levels were effective in predicting outcomes beyond the clinical variables alone.
TLR4 genetic variation is associated with inflammatory responses in Gram-positive sepsis.
Clin Microbiol Infect
January 2017
Article Synopsis
- The study aims to understand how certain genetic pathways related to pathogen recognition receptors affect immune responses in Staphylococcus aureus sepsis.
- Researchers examined a specific genetic variant in the TLR4 gene and its association with cytokine responses to S. aureus in both laboratory settings and a cohort of Thai patients with sepsis.
- Findings suggest that a variant in TLR4 is linked to increased cytokine levels and respiratory failure in patients, indicating that immune responses to S. aureus share similarities with responses to Gram-negative bacteria, despite S. aureus not activating TLR4 directly.
Staphylococcus argenteus is a globally distributed cause of human infection, but diagnostic laboratories misidentify this as Staphylococcus aureus. We determined whether there is clinical utility in distinguishing between the two. A prospective cohort study of community-onset invasive staphylococcal sepsis was conducted in adults at four hospitals in northeast Thailand between 2010 and 2013.
View Article and Find Full Text PDFBackground: Little is known about the epidemiology of nosocomial bloodstream infections in public hospitals in developing countries. We evaluated trends in incidence of hospital-acquired bacteremia (HAB) and healthcare-associated bacteremia (HCAB) and associated mortality in a developing country using routinely available databases.
Methods: Information from the microbiology and hospital databases of 10 provincial hospitals in northeast Thailand was linked with the national death registry for 2004-2010.
Background: As increasing numbers of children initiate antiretroviral treatment (ART), a systematic process is needed to measure and improve pediatric HIV care quality.
Methods: Pediatric HIVQUAL-T, a model for performance measurement and quality improvement (QI), was adapted from the U.S.
Background: Invasive Staphylococcus aureus infection is increasingly recognised as an important cause of serious sepsis across the developing world, with mortality rates higher than those in the developed world. The factors determining mortality in developing countries have not been identified.
Methods: A prospective, observational study of invasive S.