Study on Depressant Effects and Muscle Coordination Activity of Stem Methanol Extract.

Background: is an evergreen shrub found across peninsular India, belonging to family .

Objective: The objective of this study was to assess the depressant effects and muscle coordination activity of stem methanol extract (GGSME).

Materials And Methods: The stem methanol extract was administered in Swiss albino mice in 1 day to study the central nervous system (CNS) depressant and muscle coordination activity employing animal models such as sodium pentobarbital-induced sleep test, hole-board test, open field test, pentylenetetrazole (PTZ)-induced convulsions, picrotoxin-induced convulsions, grip strengthening test in mice, and Rota-rod test.

Biotransformation of valdecoxib by microbial cultures.

Microbial biotransformations can be used to predict mammalian drug metabolism. The present investigation deals with microbial biotransformation of valdecoxib using microbial cultures. Thirty nine bacterial, fungal and yeast cultures are used to elucidate the biotransformation pathway of valdecoxib.