Prevalence of extrapulmonary tuberculosis and factors influencing successful treatment outcomes among notified cases in South India.

Tuberculosis (TB) remains a significant public health issue globally, with extra pulmonary tuberculosis (epTB) accounting for a considerable number of TB cases. This study aims to improve our understanding of epTB epidemiology by evaluating treatment outcomes and identifying factors associated with positive and negative treatment results in epTB patients. A retrospective study was conducted from January 1, 2016, to December 31, 2019.

Impact of rpoB gene mutations and Rifampicin-resistance levels on treatment outcomes in Rifampicin-resistant tuberculosis.

Background: Although many studies have examined the connection between mutations in the rpoB gene and drug resistance, the impact of common mutations on treatment outcomes for RR-TB is not yet fully understood.

Objectives: This study explores the relationship between rpoB gene mutations and drug-resistant phenotypes, assesses their role in predicting RR-TB prognosis, and investigates the impact of disputed rpoB mutations in M. tuberculosis on treatment outcomes.