Publications by authors named "Sriram S Paravastu"
Article Synopsis
- The study evaluated how well GPT-4 could create understandable patient education materials for common interventional radiology procedures.
- A total of 10 procedures were assessed, with input from both clinical physicians and nonclinical assessors to measure clarity, appropriateness, and readability.
- Results indicated GPT-4 generated instructions that were generally appropriate and easier to read than existing patient resources, showing better accessibility for patients in terms of language complexity.
Article Synopsis
- Stem cell therapies for cartilage disease are hindered by a lack of understanding of cartilage formation and maintenance.
- Human bone marrow stromal cells (hBMSCs) can create stable cartilage when using hyaluronic acid-coated microbeads, but the exact mechanisms are not fully understood.
- Although hBMSCs failed to repair cartilage in rodents, cells derived from chondrospheroids showed promising results by forming lasting non-hypertrophic cartilage.
Osteoporosis is a metabolic bone disorder that leads to a decline in bone microarchitecture, predisposing individuals to catastrophic fractures. The current standard of care relies on detecting bone structural change; however, these methods largely miss the complex biologic forces that drive these structural changes and response to treatment. This review introduces sodium fluoride (18F-NaF) positron emission tomography/computed tomography (PET/CT) as a powerful tool to quantify bone metabolism.
View Article and Find Full Text PDFPositron emission tomography (PET) offers an incredible wealth of diverse research applications in vascular disease, providing a depth of molecular, functional, structural, and spatial information. Despite this, vascular PET imaging has not yet assumed the same clinical use as vascular ultrasound, CT, and MR imaging which provides information about late-onset, structural tissue changes. The current clinical utility of PET relies heavily on visual inspection and suboptimal parameters such as SUVmax; emerging applications have begun to harness the tool of whole-body PET to better understand the disease.
View Article and Find Full Text PDFMalignant lymphomas are a family of heterogenous disorders caused by clonal proliferation of lymphocytes. F-FDG-PET has proven to provide essential information for accurate quantification of disease burden, treatment response evaluation, and prognostication. However, manual delineation of hypermetabolic lesions is often a time-consuming and impractical task.
View Article and Find Full Text PDFThis review discusses the current state of artificial intelligence (AI) in F-NaF-PET/CT imaging and the potential applications to come in diagnosis, prognostication, and improvement of care in patients with bone diseases, with emphasis on the role of AI algorithms in CT bone segmentation, relying on their prevalence in medical imaging and utility in the extraction of spatial information in combined PET/CT studies.
View Article and Find Full Text PDFIn this case report, we focus on Muenke syndrome (MS), a disease caused by the p.Pro250Arg variant in fibroblast growth factor receptor 3 (FGFR3) and characterized by uni- or bilateral coronal suture synostosis, macrocephaly without craniosynostosis, dysmorphic craniofacial features, and dental malocclusion. The clinical findings of MS are further complicated by variable expression of phenotypic traits and incomplete penetrance.
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