Antimicrobial activities of jadomycin B and structurally related analogues.

Natural products are leads for new antibiotics as a result of their structural complexity and diversity. We have isolated a series of structurally related polyketide-derived natural products from Streptomyces venezuelae ISP5230. The most active of these jadomycin analogues showed good activity against a variety of staphylococci, including methicillin-resistant Staphylococcus aureus.

Investigations on neomycin production with immobilized cells of Streptomyces marinensis NUV-5 in calcium alginate matrix.

The purpose of this investigation was to study the effect of Streptomyces marinensis NUV-5 cells immobilized in calcium alginate for the production of neomycin. The effect of various parameters, such as the effect of alginate concentration (1%, 2%, 3%, 4%, and 5% wt/vol), the effect of cation (CaCl2, BaCl2, and SrCl2), the concentration of cation (0.01M, 0.

Studies on neomycin production using immobilized cells of S marinensis NUV-5 in various reactor configurations: a technical note.

Stirred tank, fluidized bed, and airlift reactors produced similar neomycin activity with immobilized cells. Packed bed reactor clearly under performed, probably because of insufficient aeration or mixing. Neomycin production using immobilized cells in fermentors requires good mixing and aeration.