Management parameters affecting the outcome of Japanese encephalitis.

The aim of this hospital-based, prospective interventional study was to identify the influence of various therapeutic measures on survival in children with Japanese encephalitis. Fluid restriction, avoidance of routine sedation and higher doses of mannitol were the basis of protocol A (used in the first season). Unrestricted fluid supplementation, guided by central venous pressure monitoring, along with routine sedation and a lower dose of mannitol (only when needed) was used in managing those children with a Glasgow Coma Score (GCS) less than or equal to 8 in the second season.