Management of Prenatal Expanded Genetic Carrier Screening Results for Autosomal Recessive Sensorineural Hearing Loss.

Objective: Expanded carrier screening (ECS) identified couples at-risk to have a baby with an autosomal recessive genetic condition. Several genes implicated in sensorineural hearing loss (SNHL) are included in prenatal or preconception genetics ECS testing. Early identification of SNHL risk may enable prognostication of hearing loss, early educational intervention, and minimization of unnecessary diagnostic testing.

Clinicopathological and Immunophenotypic Characteristics of Series of Re-arranged Acute Leukemias.

Rearrangement involving gene (-r) is recently being described in acute leukemias. We present the clinic-pathological and immunophenotypic findings in a series of five cases of acute leukemia with -r reported in our Institute between September 2020 to September 2023. Notably, while fusion was the most frequently encountered abnormality, the fusion partner was not identified in two patients with -r BCP-ALL.

Slice-aware 5G network orchestration framework based on dual-slice isolation and management strategy (D-SIMS).

Network slicing is crucial to the 5G architecture because it enables the virtualization of network resources into a logical network. Network slices are created, isolated, and managed using software-defined networking (SDN) and network function virtualization (NFV). The virtual network function (VNF) manager must devise strategies for all stages of network slicing to ensure optimal allocation of physical infrastructure (PI) resources to high-acceptance virtual service requests (VSRs).

Expression and Functional Characterization of Oryzacystatin II Protein from Indica Rice and Its Potential Role as a Bioinsecticide Against Major Insects of Rice.

Rice (L.) is a crucial staple food crop globally, facing significant challenges from various pests that affect crop productivity and quality. Conventional pesticide usage has limitations, necessitating the development of sustainable pest management strategies.

Bacterial microbiome associated with cigarette beetle Lasioderma serricorne (F.) and its microbial plasticity in relation to diet sources.

Insect-microbial symbiosis contributes positively to the physiology of the insect and diet is considered as one important factor determining microbial symbiosis. In this study, we have characterized the microbiota of cigarette beetle, Lasioderma serricorne (Fabricius) on different diets and phases. The beetles were reared on different diet sources (exposed phase) for six generations and were reverted to their natal source (reverted phase) and further maintained for six more generations.

An E2E Network Slicing Framework for Slice Creation and Deployment Using Machine Learning.

Network slicing shows promise as a means to endow 5G networks with flexible and dynamic features. Network function virtualization (NFV) and software-defined networking (SDN) are the key methods for deploying network slicing, which will enable end-to-end (E2E) isolation services permitting each slice to be customized depending on service requirements. The goal of this investigation is to construct network slices through a machine learning algorithm and allocate resources for the newly created slices using dynamic programming in an efficient manner.

The Global Otolaryngology-Head and Neck Surgery Workforce.

Importance: A core component of delivering care of head and neck diseases is an adequate workforce. The World Health Organization report, Multi-Country Assessment of National Capacity to Provide Hearing Care, captured primary workforce estimates from 68 member states in 2012, noting that response rates were a limitation and that updated more comprehensive data are needed.

Objective: To establish comprehensive workforce metrics for global otolaryngology-head and neck surgery (OHNS) with updated data from more countries/territories.

The gut microbiota reprograms intestinal lipid metabolism through long noncoding RNA .

The intestinal microbiota regulates mammalian lipid absorption, metabolism, and storage. We report that the microbiota reprograms intestinal lipid metabolism in mice by repressing the expression of long noncoding RNA (lncRNA) (small nucleolar RNA host gene 9) in small intestinal epithelial cells. suppressed the activity of peroxisome proliferator-activated receptor γ (PPARγ)-a central regulator of lipid metabolism-by dissociating the PPARγ inhibitor sirtuin 1 from cell cycle and apoptosis protein 2 (CCAR2).

Ceramide compensation by ceramide synthases preserves retinal function and structure in a retinal dystrophy mouse model.

Increasing evidence has supported the role of ceramide as a mediator of photoreceptor dysfunction or cell death in ceramide accumulation and deficiency contexts. TLCD3B, a non-canonical ceramide synthase, was previously identified in addition to the six canonical ceramide synthases (CerSs), and the Tlcd3b-/- mouse model exhibited both retinal dysfunction and degeneration. As previous canonical CerS-deficient mouse models failed to display retinal degeneration, the mechanisms of how TLCD3B interacts with CerSs have not been investigated.

The Role of Ceramide in Inherited Retinal Disease Pathology.

Ceramide (Cer) plays an essential role in photoreceptor cell death in the retina. On the one hand, Cer accumulation emerges as a common feature during retina neurodegeneration, leading to the death of photoreceptors. On the other hand, Cer deficiency has also recently been associated with retinal dysfunction and degeneration.

Macrophages regulate gastrointestinal motility through complement component 1q.

Peristaltic movement of the intestine propels food down the length of the gastrointestinal tract to promote nutrient absorption. Interactions between intestinal macrophages and the enteric nervous system regulate gastrointestinal motility, yet we have an incomplete understanding of the molecular mediators of this crosstalk. Here, we identify complement component 1q (C1q) as a macrophage product that regulates gut motility.

Essential equipment and services for otolaryngology care: a proposal by the Global Otolaryngology-Head and Neck Surgery Initiative.

Purpose Of Review: To highlight the need for comprehensive resource lists to provide baseline care of otolaryngologic conditions; to present a proposed list of essential equipment and services that may be applied toward surgical systems research, policymaking, and charitable efforts in global otolaryngology-head and neck surgery.

Recent Findings: To provide effective and high-quality surgical care across care settings, there must be a global standard for equipment and ancillary services necessary to provide baseline care. Though there have been efforts to devise resource standards via equipment lists and appraisal tools, these have been limited in scope to general surgery, emergency care, and a few other subspecialty surgical contexts.

Optimal Resource Allocation for 5G Network Slice Requests Based on Combined PROMETHEE-II and SLE Strategy.

The network slicing of physical infrastructure is required for fifth-generation mobile networks to make significant changes in how service providers deliver and defend services in the face of evolving end-user performance requirements. To perform this, a fast and secure slicing technique is employed for node allocation and connection establishment, which necessitates the usage of a large number of domain applications across the network. PROMETHEE-II and SLE algorithms were used in this study's approach to network design for node allocation and link construction, respectively.

Exome Sequencing Expands the Genetic Diagnostic Spectrum for Pediatric Hearing Loss.

Objectives: Genetic testing is the standard-of-care for diagnostic evaluation of bilateral, symmetric, sensorineural hearing loss (HL). We sought to determine the efficacy of a comprehensive genetic testing method, exome sequencing (ES), in a heterogeneous pediatric patient population with bilateral symmetric, bilateral asymmetric, and unilateral HL.

Methods: Trio-based ES was performed for pediatric patients with confirmed HL including those with symmetric, asymmetric, and unilateral HL.

A brief review on oryzacystatin: a potent phytocystatin for crop management.

Phytocystatins are a type of proteinase inhibitor which are extensively studied for their specific inhibitory action against cysteine protease enzymes (CP) of insects and pathogens. Oryzacystatins (OC), a phytocystatin from rice inhibits CP in a reversible manner with its conserved tripartite wedge. OCs have important role in plant innate defense mechanism through phytohormonal signalling pathways.

The Importance of Signal Strength Index in Optical Coherence Tomography Angiography: A Study of Eyes with Pseudoexfoliation Syndrome.

Purpose: To evaluate the effect of the signal strength index (SSI) on a comparison of the vascular and structural OCT measurements between eyes with pseudoexfoliation syndrome (PXF) and healthy controls of Asian-Indian origin.

Methods: In this cross-sectional study, 33 eyes of 33 PXF patients and 40 healthy eyes of 40 controls underwent OCT and OCT angiography (OCTA). Eyes with intraocular pressure (IOP) >21mmHg, glaucomatous disc changes, or any other ocular pathology were excluded.

Polyphagous insect sps feeding on cardenolide rich (L.) leaves and detoxification mechanism involving GST.

Cardenolides, a group of cardiac glycosides are potent inhibitors of Na/K ATPase pump in mammals, animals including insects. Some insects can circumvent the toxicity of cardenolides by mechanisms like target site resistance and metabolic resistance resulting in enhanced tolerance or adaptation. In this paper, we report an intriguing observation of a polyphagous feeder feeding gregariously on the leaves of (L.

Insights on the Dynamics and Toxicity of Nanoparticles in Environmental Matrices.

The manufacturing rate of nanoparticles (10-100 nm) is steadily increasing due to their extensive applications in the fabrication of nanoproducts related to pharmaceuticals, cosmetics, medical devices, paints and pigments, energy storage etc. An increase in research related to nanotechnology is also a cause for the production and disposal of nanomaterials at the lab scale. As a result, contamination of environmental matrices with nanoparticles becomes inevitable, and the understanding of the risk of nanoecotoxicology is getting larger attention.

An invasive weed-associated bacteria confers enhanced heat stress tolerance in wheat.

Global temperatures are expected to increase due to climate change, and heat stress is one of the major limiting factors affecting future agriculture. To identify plant-associated microorganisms which can promote heat stress tolerance in wheat, we have screened several bacteria isolated from etiolated seedlings of the invasive noxious weed . One isolate designated as Ph-04 was found to confer enhanced heat stress tolerance in wheat.