Morphological Abnormalities Classification of Red Blood Cells Using Fusion Method on Imbalance Datasets.

Red blood cells (RBCs) or Erythrocytes are essential components of the human body and they transport oxygen from the lungs to the body's tissues, regulate balance, and support the immune system. Abnormalities in RBC shapes (Poikilocytosis) and sizes (Anisocytosis) can impede oxygen-carrying capacity, leading to conditions such as anemia, thalassemia, McLeod Syndrome, liver disease, and so on. Hematologists typically spend considerable time manually examining RBC's shapes and sizes using a microscope and it is time-consuming.

Patterns, timing and predictors of recurrence following pancreaticoduodenectomy for pancreatic ductal adenocarcinoma: an international multicentre retrospective cohort study.

Background: Most patients undergoing pancreaticoduodenectomy (PD) for pancreatic ductal adenocarcinoma (PDAC) develop recurrence. No previous studies have investigated predictors of local-only recurrence following PD for PDAC. Our study aimed to determine timing, pattern and predictors of any-site and local-only recurrence following PD for PDAC.

Probe-infused polymer monolithic sensor for colorimetric detection of Pb in environmental water samples and tobacco extracts.

This study focuses on developing an affordable and cost-effective colorimetric solid-state optical sensor for target-specific naked-eye detection of Pb, offering significant potential for real-time environmental monitoring and public health applications. The indigenously developed porous polymer monolithic template, poly(lauryl methacrylate-co-ethylene glycol dimethacrylate) (poly(LMC-co-EGDMA) is infused with a chromoionophoric probe, i.e.

Neuroendocrine prostate cancer drivers SOX2 and BRN2 confer differential responses to imipridones ONC201, ONC206, and ONC212 in prostate cancer cell lines.

Objectives: Prostate cancer (PCa) is a leading cause of cancer death in men worldwide. Approximately 30% of castrate-resistant PCa becomes refractory to therapy due to neuroendocrine differentiation (NED) that is present in <1% of de-novo tumors. First-in-class imipridone ONC201/TIC10 therapy has shown clinical activity against midline gliomas, neuroendocrine tumors, and PCa.

TRAIL agonists rescue mice from radiation-induced lung, skin or esophageal injury.

Radiotherapy can be limited by pneumonitis which is impacted by innate immunity, including pathways regulated by TRAIL death receptor DR5. We investigated whether DR5 agonists could rescue mice from toxic effects of radiation and found two different agonists, parenteral PEGylated trimeric-TRAIL (TLY012) and oral TRAIL-Inducing Compound (TIC10/ONC201) could reduce pneumonitis, alveolar-wall thickness, and oxygen desaturation. Lung protection extended to late effects of radiation including less fibrosis at 22-weeks in TLY012-rescued survivors versus un-rescued surviving irradiated-mice.

and Evaluation of the Cytotoxic Potential of Hinokitiol against Osteosarcoma by Targeting Glycogen Synthase Kinase 3β.

Objectives: The present study aimed to assess the antiproliferative and pro-apoptotic effects of hinokitiol in osteosarcoma cells and targeting of glycogen synthase kinase 3 (GSK3).

Materials And Methods: The (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay was used to evaluate the cytotoxic potential of hinokitiol in osteosarcoma cells. Various concentrations of hinokitiol (5, 10, 20, 40, 60, and 80 μg/mL) were tested, and the half-maximal inhibitory concentration (IC) was calculated.

Ecofriendly Synthesis of Nickel Oxide Nanoparticles From Fissidens Species and Its Biological Applications.

The present study was performed to synthesize eco-friendly nickel oxide nanoparticles (NiONPs) from the aqueous extract of Fissidens species (FS) and explore its biological activities. Phytochemicals, namely, alkaloids, flavonoids, sterols, tannins, proteins, carbohydrates and phenols, were present in the aqueous extract of Fissidens sp. The UV-Vis and FT-IR analyses of FS-NiONPs revealed a prominent peak at 392 nm, along with functional groups that facilitate the formation of FS-NiONPs.

Factors impacting sleep center no-show rates post hospital discharge utilizing geospatial coding in Appalachia.

Study Objectives: Screening for early detection of sleep-disordered breathing (SDB) in hospitalized patients has been shown to reduce readmission rates. However, post-discharge polysomnography for confirmation of diagnosis is required. We analyzed factors for "no-shows" using geospatial techniques.

Delayed surgery during the Covid-19 pandemic did not affect long-term outcomes of pancreatic adenocarcinoma.

Background: During the Covid-19 pandemic cancer surgery was severely affected due to relocation of healthcare resources and the resulting restructuring of cancer pathways. Although this potentially affected rapidly progressing malignancies like pancreatic cancer the most, little is known about long-term outcomes following pancreatectomy.

Materials And Methods: Survival data from two pancreatic surgery centres in the UK was analysed with patients being compared across pre-pandemic (C19-) and intra-pandemic (C19+) groups.

High Prevalence of Sarcopenia in Patients with Newly Diagnosed Gastroenteropancreatic Neuroendocrine Tumours (GEP-NETs), but No Association with the Risk of Surgical Complications.

Sarcopenia is a muscle disease that occur across a lifetime. It is commonly described in the aging population but can occur earlier in life in patients with cancer. Previous studies demonstrated sarcopenia is highly prevalent in patients with gastroenteropancreatic neuroendocrine tumours (GEP-NETs).

Luminescent Silver Nanoparticles Biosynthesis Using Couroupita guianensis Flower Extract: Antibacterial and Anticancer Potential.

Green synthesis of nanoparticles has become a significant area of research, driven by the demand for sustainable, economical, and environmentally friendly processes, particularly in biomedical applications. In this study, silver nanoparticles (AgNPs) were produced using 10 g of Couroupita guianensis flower extract through a straightforward and environmentally friendly method. The biosynthesized AgNPs were characterized using UV-Vis spectroscopy, XRD, FTIR, SEM, and EDS techniques, confirming their successful formation and structural properties.

Fruit Extract Mediated Formation of Luminescent Titanium Dioxide Nanometer-Sized Particles: An Innovative Strategy in Domain of Photodecomposition and Germicidal Properties.

Discoveries in nanotechnologies are placing a great deal of attention on greener strategies that use harmless substances and moderated reactions to promote healthy development. This work used a straightforward, innovative, and cost-effective sustainable approach to produce bio-augmented TiO nanometer-sized particles (NMSP) by applying a water-based extract of the star fruit as a stabilization and reduction agent. A variety of techniques, comprising UV-Vis, XRD, FT-IR, FE-SEM with EDAX, and TEM, have been employed to investigate the formed TiO NMSP.

Long-Term Outcomes of Stereotactic Radiosurgery for Pineocytomas: An International Multicenter Study.

Background And Objectives: Pineocytomas are grade 1 tumors arising from the pineal parenchyma. Gross total resection can potentially cure these benign lesions but can be associated with morbidity. This study was designed to provide multi-institutional data to evaluate the results of stereotactic radiosurgery (SRS) for pineocytomas.

Development of Luminescent and Photosensitive Cellulose Microfibers From Palm Sprout Fibers: Antibacterial Efficacy and Dye Adsorption Potential.

A key contemporary challenge is enhancing the value of agro-industrial byproducts. Cellulose, the most abundant renewable resource, offers significant industrial potential due to its versatile properties. Produced in its pure form by various bacteria, cellulose is increasingly utilized in microscale and nanoscale fibers for composite reinforcement.

Fluorescent Microscopy Investigation of Cytotoxic Impact on MCF-7 Cell Line Treated With Zinc Nanoparticles Synthesized From Jania rubens.

Zinc nanoparticles (ZnNPs) are a viable option in a number of disciplines, including cancer treatment, due to their special features. Among the several techniques for synthesizing ZnNP, biosynthesis with natural extracts is a highly effective and environmentally benign method, especially for uses in biomedicine. Using an aqueous extract of the marine red seaweed Jania rubens, we created a unique biosynthetic technique in this study to manufacture ZnNPs.

Fabrication of Luminescent Titanium Dioxide Nanoparticles in a Biocompatible Approach: Its Potential for Photodecomposition and Germicidal Effects.

The fabrication of the green strategy of metallic oxide creation provides considerable profits via a minimum of effort, making it an acceptable substitute to the most laborious and challenging conventional processes. The suggested approach involved the creation of titanium dioxide (TiO) nanoparticles through Orthosiphon stamineus extracts of leaves. The synthesized nanoparticles (NPs) were then characterized using XRD, FT-IR, FE-SEM with EDX, and UV-visible spectroscopy.

Growth, characterization and cognition of 2-cyanopyridinium perchlorate single crystals for nonlinear optical applications.

The fascinating electronic applications attracted researchers to explore the field of nonlinear optical (NLO) materials. The slow evaporation of solvent technique (SEST) was employed to grow the 2-cyanopyridinium perchlorate (2-CPPC) NLO single crystals. The cell parameters of the grown 2-CPPC crystal are confirmed by the single crystal X-ray diffraction (SCXRD) study.

Time-Dependent Hydrothermal Synthesis of LaO NPs for Effective Catalytic Activity of Ionic Dye.

Lanthanum oxide was successfully synthesized by hydrothermal method by varying the reaction time such as 6, 12, and 24 h. In XRD, study confirms the presence of a hexagonal structure, and the phase remains the same at different times; the main goal is to assess the average crystallite size of prepared LaO nanoparticles, which was found in the range of 6 to 8 nm. An interesting observation from the XRD data was the apparent increase in crystalline nature as the synthesis time was extended.

Design, synthesis, molecular modeling and evaluation of 2,4-diaminopyrimidine analogues as promising colorectal cancer drugs.

The potential of cyclin-dependent kinases (CDKs) as therapeutic targets in cancer treatment is well established. In this study, we present our investigation into a group of 2,4-diaminopyrimidine derivatives that potently inhibit CDK9 and are cytotoxic when tested in colorectal cancer cell lines. We designed and synthesized forty analogues by altering substitutions at C-2 and C-4 position of the pyrimidine system.

Synthesis of Luminescent Copper Nanoparticles Using Couroupita guianensis Flower Extract: Evaluation of Antibacterial and Anticancer Activities.

The biosynthesis of nanoparticles is a crucial research area aimed at developing innovative, cost-effective, and eco-friendly synthesis techniques for various applications. Herein, we synthesized copper oxide nanoparticles (CuNPs) using Couroupita guianensis flower extract via a simple green synthesis method. These green CuNPs demonstrate promising antimicrobial activity and anticancer activity against A549 nonsmall cell lung cancer (NSCLC) cells.

Modular component exchange has no advantage in Debridement, Antibiotics and Implant Retention (DAIR) for early onset hip and knee prosthetic joint infection.

Introduction: Debridement, Antibiotics and Implant Retention (DAIR) has been the mainstay of treatment for early onset periprosthetic joint infection in spite of variable results. Modular component exchange is a widely recommended strategy to improve success rates with DAIR though very strong evidence to support its practice is still lacking.

Materials And Methods: Eighty six patients underwent DAIR for early onset PJI following primary hip and knee arthroplasty were divided into two groups for this retrospective review.

Plasmodium RON11 triggers biogenesis of the merozoite rhoptry pair and is essential for erythrocyte invasion.

Malaria is a global and deadly human disease caused by the apicomplexan parasites of the genus Plasmodium. Parasite proliferation within human red blood cells (RBCs) is associated with the clinical manifestations of the disease. This asexual expansion within human RBCs begins with the invasion of RBCs by P.