Publications by authors named "Srinivasan M"

The purpose of this article was to present a novel clinical workflow for the fabrication of complete dentures using computer-aided design and computer-aided manufacturing (CAD-CAM) technology. The dental technique consists of 3 clinical steps and 2 laboratory phases that result in the production of 2 CAD-CAM milled complete denture bases with prefabricated teeth. The integration of analog and digital procedures and materials maximizes their benefits in the planning and fabrication of complete dentures, with the goal of improving clinical outcomes.

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Objectives: This double-blind randomised crossover trial aimed to compare the aesthetic outcomes of CAD-CAM manufactured provisional restorations created using cone beam computed tomography (CBCT) and intraoral scanners (IOS) acquisition methods.

Methods: Twelve participants (mean-age: 38 ± 5 years) requiring full mouth rehabilitation were included in this crossover trial. Two sets of identical CAD-CAM provisional restorations, differing only in the method of data acquisition (A: CBCT, B: IOS), were fabricated.

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Background: Cardiovascular disease (CVD) prevalence varies widely among Asian American adults. The American Heart Association added healthy sleep to its metrics to define ideal cardiovascular health. Little is known about the association between sleep and CVD prevalence among Asian subgroups.

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In this study, we investigate the performance of computer vision AI algorithms in predicting patient disposition from the emergency department (ED) using short video clips. Clinicians often use "eye-balling" or clinical gestalt to aid in triage, based on brief observations. We hypothesize that AI can similarly use patient appearance for disposition prediction.

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Aim: This study aimed to evaluate nurses' baseline understanding of diagnostic stewardship (DS) principles and the impact of an educational intervention on their knowledge and practices.

Background: Antimicrobial resistance (AMR), driven by inappropriate antibiotic use, is a critical global health threat. Effective antimicrobial stewardship (AMS) requires integrating DS to ensure accurate diagnoses through proper test requisition, specimen handling and timely reporting.

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Objectives: This study was conducted to determine and correlate the perception of social support and the prevalence of self-reported depressive symptoms among patients with head-and-neck squamous cell carcinoma (HNSCC).

Materials And Methods: This cross-sectional study included 100 patients with HNSCC receiving treatment at a tertiary cancer centre in north India. They were enrolled by a convenient sampling technique.

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Purpose: Coffee consumption is a well-known contributor to tooth discoloration, and the extent of staining is influenced by the chemical composition of the coffee. This study investigated the associations of coffee roasting level, chlorogenic acid (CGA) content, absorbance level, and their combined effects with tooth discoloration.

Methods: Bovine tooth enamel specimens were immersed in light, medium, and dark roasts of four coffee types (two Arabica and two Robusta coffees) for 72 h.

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Article Synopsis
  • - The study examined the prevalence of oral hypofunction (OHF) among 155 healthy adults across different age groups and sexes, assessing various oral functions like hygiene, dryness, and masticatory abilities.
  • - Results indicated that older adults (65+) had a significantly higher prevalence of OHF compared to younger (20-39) and middle-aged (40-64) groups, with marked deterioration in specific measures related to age.
  • - Hand grip strength was positively correlated with certain oral functions, suggesting a linkage between oral health and overall physical ability, particularly in both male and female participants.
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Objective: This pilot study assessed the feasibility of using facial thermography to detect intra-oral problems in older adults with cognitive decline and care-resistant behaviors, who are often unable to communicate pain or early symptoms.

Methods: Twenty-three older adults (mean age 73.7 ± 13.

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Objective: This study aimed to correlate the bite/occlusal force measurements obtained through two methods: a hydraulic pressure gauge with a biting transducer (GM-10), and a computer-assisted device that records occlusal force on a pressure-sensitive film (Prescale II).

Methods: Healthy, dentate volunteers were recruited. Participants' demographic data included age, sex, number of teeth present, presence of oral pain, history of prior orthodontic treatment and presence of parafunction.

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  • The study explores the effects of carvacrol zinc oxide quantum dots (CVC-ZnO QDs) on breast cancer MCF-7 cells and mammary cancer models, focusing on their molecular interactions and biological impacts.
  • Using molecular docking analysis, CVC was found to have strong binding affinities with key proteins in the PI3K/AKT/mTOR pathway, which are crucial for cell growth and survival.
  • The research demonstrated that CVC-ZnO QDs have a dose-dependent cytotoxic effect on MCF-7 cells, leading to increased oxidative stress and apoptosis, suggesting their potential use as a therapeutic strategy for breast cancer treatment.
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  • The Stanford Clinical Summer Internship (CSI) was evaluated to assess its effectiveness in exposing high school and college students to various healthcare careers, emphasizing engagement in both in-person and virtual formats.
  • Survey results from 173 participants revealed that a significant majority felt the program broadened their medical perspectives, increased their interest in healthcare careers, and provided valuable clinical skills, with minimal differences noted between high school and college students.
  • In-person participants valued friendships formed during the program more, while virtual participants showed a stronger interest in research careers; overall, the internship positively influenced the educational and career paths of many respondents.
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  • Taste dysfunction is a common symptom in individuals with long COVID, with 20-25% experiencing persistent issues, particularly with bitter taste perception.
  • The study found that people with long COVID had significantly lower levels of salivary gustin, a protein that affects taste, which correlated with a reduced ability to taste bitterness.
  • Sonic hedgehog (SHH) and other specific cell markers were identified in saliva, indicating potential mechanisms behind taste dysfunction in long COVID patients.
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Introduction: COPD is characterised by airflow obstruction, expiratory airway collapse and closure causing expiratory flow limitation (EFL) and hyperinflation. Supine posture may worsen ventilatory function in COPD, which may cause hyperinflation to persist and contribute to symptoms of orthopnoea and sleep disturbance. Our aim was to determine the impact of supine posture on hyperinflation, dynamic elastance and EFL in COPD and healthy subjects.

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Introduction: Two thirds of Americans infected with chronic hepatitis B are unaware of their infection. In March 2023, the Centers for Disease Control and Prevention recommended moving from risk-based to universal adult chronic hepatitis B screening. In April 2022, Stanford implemented chronic hepatitis B universal screening discussion alerts for primary care providers.

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Objectives: There is limited information about the stability and predictability of Bayley Scales of Infant and Toddler Development (BSID) assessing child development in low- and middle-income settings. The objective of the present study was to analyse stability and predictive validity of BSID using an existing birth cohort.

Design: Prospective birth cohort follow-up study.

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A tremendous amount of recent work has been done on different metal oxide nanomaterials for biological activities and photocatalytic dye degradation. This work used the Cissus quadrangularis leaf extract to prepare TiO, CdO, MnO, and ZnO nanoparticles using a green synthesis approach. To ascertain the physicochemical characteristics of the generated metal oxide nanoparticles, various characterisation techniques were used.

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Humans adapt their locomotion seamlessly in response to changes in the body or the environment. It is unclear how such adaptation improves performance measures like energy consumption or symmetry while avoiding falling. Here, we model locomotor adaptation as interactions between a stabilizing controller that reacts quickly to perturbations and a reinforcement learner that gradually improves the controller's performance through local exploration and memory.

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Human biomechanical data are often accompanied with measurement noise and behavioral variability. Errors due to such noise and variability are usually exaggerated by fewer trials or shorter trial durations, and could be reduced using more trials or longer trial durations. Speeding up such data collection by lowering number of trials or trial duration, while improving the accuracy of statistical estimates, would be of particular interest in wearable robotics applications and when the human population studied is vulnerable (e.

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Objectives: To evaluate the accuracy in tooth shade selection under various lighting conditions using different devices, including a color spectrophotometer (CSP) and two intra-oral scanners (IOS: IOS-1 and IOS-2).

Methods: Tooth shade measurements were performed on a standardized shade guide (16 shades, A1-D4) using CSP, IOS-1 and IOS-2. These evaluations were carried out under three lighting conditions: (1) DL - device light source only, (2) RL - DL plus room light, and (3) CL - RL plus dental-chair light.

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Article Synopsis
  • - Anthropogenic pressures are causing an increase in environmental disturbances, leading to significant declines in wild plant and animal populations, particularly in coral reef ecosystems, which are already vulnerable to such changes.
  • - A study spanning 12-14 years across four regions of the Great Barrier Reef examined how various disturbances influenced coral reef fish populations, revealing that long recovery periods were insufficient to prevent a drastic decline in fish density and species richness.
  • - The research highlighted regional differences in the main drivers of change, with the most significant impacts observed after cyclones and floods, and concluded that small marine reserves offer limited protection against the effects of frequent climatic disturbances and the need for larger-scale conservation efforts.
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  • The study examines cancer mortality rates among different Hispanic subgroups in the US over 15 years, focusing on variations based on nativity (native- or foreign-born).
  • Analysis of over 228,000 cancer deaths suggests that Puerto Rico-born, Cuba-born, and US-born Mexicans face some of the highest cancer mortality rates, with foreign-born Hispanics generally having higher rates than US-born, except Mexicans.
  • The findings highlight significant differences in cancer mortality by nativity within Hispanic populations, underscoring the need for tailored health resources to address these disparities.
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Background: Limited digital literacy is a barrier for vulnerable patients accessing health care.

Objective: The Stanford Technology Access Resource Team (START), a service-learning course created to bridge the telehealth digital divide, trained undergraduate and graduate students to provide hands-on patient support to improve access to electronic medical records (EMRs) and video visits while learning about social determinants of health.

Methods: START students reached out to 1185 patients (n=711, 60% from primary care clinics of a large academic medical center and n=474, 40% from a federally qualified health center).

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Background: As the US population ages, there is an increasing demand for home-based primary care (HBPC) by those with Alzheimer's/dementia, multiple chronic conditions, severe physical limitations, or those facing end-of life. Nurse practitioners (NPs) are increasingly providing HBPC, yet little is known about their quality of care in this unique setting.

Methods: This observational study uses Medicare claims data from 2018 to assess the quality of care for high-intensity HBPC users (5 or more visits/year) based on provider type (NP-only, physician (MD)-only, or both NP and MDs).

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