Effect of visualization of raw graphic polysomnography data by sleep apnea patients on adherence to CPAP therapy.

Background: CPAP is considered to be the cornerstone of therapy for obstructive sleep apnea. However, adherence to this treatment is frequently poor, which may lead to ongoing symptoms, including daytime sleepiness and poor cognitive function. We aimed to determine the efficacy of showing patients their raw graphic polysomnography (PSG) data in increasing their CPAP adherence.

Effect of HSP70 and 90 in modulation of JNK, ERK expression in preeclamptic placental endothelial cell.

Preeclampsia is a disease of worldwide significance with increasing maternal mortality rate of 20-80 %. Though apoptosis is a normal constituent during pregnancy, there seems to be an altered balance between proliferation and apoptosis of endothelial cell in preeclampsia leading to a placental dysregulation resulting in premature delivery. Molecular chaperones like HSP70 and 90 play a significant role in control of preeclamptic progression and protect the developing fetus.

Mechanism of JNK signal regulation by placental HSP70 and HSP90 in endothelial cell during preeclampsia.

Context: Preeclampsia is a placenta related disorder of during pregnancy resulting in pre- and post-partum complications of the both mother and fetus. It is associated with improper trophoblast invasion and maternal endothelial cell dysfunction leading to a placental dysregulation resulting in premature delivery.

Objective: Aim of the present study is to elucidate of the protective role of chaperones (HSP70 and 90) in preeclampsia and to test whether it is associated with oxidative stress level in placental tissue.

HSP70-mediated control of endothelial cell apoptosis during pre-eclampsia.

Objective: Pre-eclampsia is a hypertensive disorder characterized by maternal vascular endothelial dysfunction. It is likely that this enhanced rate of endothelial cell stress is associated with the pre- and post-partum complications of both mother and fetus. Deciphering the expression pattern of factors involved in altering placental endothelial cell viability in pre-eclampsia aids in identifying components that may protect the fetus from the consequences of placental dysfunction and oxidative stress.

Over expression of HSP70 and HSF1 in endothelial cells during pre-eclamptic placental stress.

Unlabelled: BACKGROUND AIM: Pre-eclampsia is a hypertensive disorder characterised by endothelial dysfunction and is one of the leading cause of preterm birth. Increasing oxidative stress and antioxidant disequilibria promote apoptosis and may play a defining role in the development of pre-eclampsia. Heat shock protein 70 (HSP70) is an effective molecular chaperone, playing a role in cell protection from damage in response to stress stimuli.

HSP70 overexpression in response to ureaplasma urealyticum-mediated oxidative stress in preeclamptic placenta.

Objective: To determine the effect of Ureaplasma urealyticum infection on oxidative stress during preeclampsia.

Methods: The relationship between oxidative stress and U. urealyticum infection was monitored through the estimation of lipid hydroperoxidation level (LHP), glutathione redox ratio (GRR), and total antioxidant capacity (TAC) along with heat shock protein 70 (HSP70) expression in the placenta.

Effect of yoga in chronic obstructive pulmonary disease.

Yoga is adjunctively utilized outside the United States in the treatment of a variety of diseases, including chronic obstructive pulmonary disease (COPD), but there are no studies assessing its adjunctive efficacy in the United States. We prospectively evaluated the effects of yoga training on the quality of life (QOL) and the parameters of lung function in patients with COPD. Thirty-three patients with documented COPD, per Global Initiative for Obstructive Lung Disease criteria, were recruited.

Preeclamptic placental stress and over expression of mitochondrial HSP70.

Background: Evidence is accumulating that mitochondrial (Mt) oxidative stress plays a role in the pathogenesis of preeclampsia. The current study analyzes the stress levels, energy status and associated enzymatic alteration in placental mitochondria of preeclamptic (n=30) and normotensive (n=35) subjects.

Methods: Total Mt stress was measured using dichlorofluorescin (DCFH) oxidant analysis, malondialdehyde (MDA) concentrations, protein carbonyl (PC) concentrations and measurement of nitrite (NO2(-)) and nitrate (NO3(-)).

Renin angiotensin system blockade and cardiovascular outcomes in patients with chronic kidney disease and proteinuria: a meta-analysis.

Objective: The role of renin angiotensin system (RAS) blockade in controlling hypertension and the positive impact on cardiovascular (CV) outcomes is well known. However, the role of RAS blockade in improving CV outcomes in patients with chronic kidney disease (CKD) is still unclear.

Methods: Randomized controlled trials that analyzed CV outcomes in patients with CKD/proteinuria treated with RAS blockade (angiotensin-converting enzyme inhibitors/angiotensin receptor blockers) were included in our study.

Clinical utility of cardiac troponin I in the diagnosis of acute coronary syndrome in patients with renal failure.

To analyze sensitivity and specificity of cardiac troponin I (cTnI) in detecting obstructive coronary artery disease in African American population with renal insufficiency presenting with acute coronary syndrome. Retrospective analysis of 108 patients who underwent coronary angiography over a 3-year period in a single institution. A troponin I level of 0.