Usability of Ultrasonic Frequency Testing for Rapid Generation of High and Very High Cycle Fatigue Data.

Ultrasonic fatigue testing is an increasingly used method to study the high cycle fatigue (HCF) and very high cycle fatigue (VHCF) properties of materials. Specimens are cycled at an ultrasonic frequency, which leads to a drastic reduction of testing times. This work focused on summarising the current understanding, based on literature data and original work, whether and how fatigue properties measured with ultrasonic and conventional equipment are comparable.

Bisphosphonate treatment of type I diabetic mice prevents early bone loss but accentuates suppression of bone formation.

Type I (T1) diabetes is an autoimmune and metabolic disease associated with bone loss. Previous studies demonstrate that T1-diabetes decreases osteoblast activity and viability. Bisphosphonate therapy, commonly used to treat osteoporosis, is demonstrated to inhibit osteoclast activity as well as osteoblast apoptosis.

The effects of damage accumulation on the tensile strength and toughness of compact bovine bone.

Damage accumulation in compact bovine femur subjected to uniaxial tensile loading was examined by strong light illumination effects of microcracking. Imaging was done using a high-speed camera capturing image at 200 to 1500FPS. The tensile tests were performed in a multipurpose tensile testing system with cross-head speeds ranging from 0.

CCAAT/enhancer binding protein β-deficiency enhances type 1 diabetic bone phenotype by increasing marrow adiposity and bone resorption.

Bone loss in type 1 diabetes is accompanied by increased marrow fat, which could directly reduce osteoblast activity or result from altered bone marrow mesenchymal cell lineage selection (adipocyte vs. osteoblast). CCAAT/enhancer binding protein beta (C/EBPβ) is an important regulator of both adipocyte and osteoblast differentiation.

Finite element analysis of ramming in Ovis canadensis.

The energy produced during the ramming of bighorn sheep (Ovis canadensis) would be expected to result in undesirable stresses in their frontal skull, which in turn would cause brain injury; yet, this animal seems to suffer no ill effects. In general, horn is made of an α-keratin sheath covering a bone. Despite volumes of data on the ramming behavior of Ovis canadensis, the extent to which structural components of horn and horn-associated structure or tissue absorb the impact energy generated by the ramming event is still unknown.