Correction of Hypothyroidism Leads to Change in Lean Body Mass without Altering Insulin Resistance.

Background: Hypothyroidism is associated with insulin resistance, dyslipidemia, and abnormal body composition. This study assessed changes in body composition and insulin resistance after thyroxine (T) replacement in overt hypothyroidism.

Methods: In this prospective longitudinal study carried out in a tertiary care center, adult nondiabetic patients with overt hypothyroidism were rendered euthyroid on T.