Development and substantiation of a liquid chromatographic method for monitoring organic reactions involved in synthesis of 4-methoxyphenylacetic acid.

A simple and rapid reversed-phase high-performance liquid chromatographic method for monitoring the reactions involved in two different processes for the production of 4-methoxyphenylacetic acid (PMPA) was developed. Impurity profiles of PMPA were used for fingerprinting of the two different synthetic processes by HPLC. Impurities were separated and determined on a Hypersil C18 column with acetonitrile-0.