Adolescent Superficial CD34-Positive Fibroblastic Tumor With Unique IHC Profile.

Superficial CD34-positive fibroblastic tumor (SCD34FT) is a relatively uncommon soft tissue neoplasm, first identified in 2014 and included in the latest, fifth edition of the World Health Organization Soft Tissue and Bone Tumors Classification. A subset of SCD34FTs that exhibit PRDM10 rearrangement may overlap with other PRDM10-rearranged soft tissue tumors, suggesting a shared pathogenic pathway. We report a case of a 16-year-old patient, one of the youngest diagnosed, with an SCD34FT on the forearm, featuring both PRDM10 rearrangement and a unique, diffuse expression of cytokeratin (CK AE1/AE3).

Cytopathology of primary sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid: a multi-institutional case series and review of literature.

Introduction: Sclerosing Mucoepidermoid Carcinoma with Eosinophilia (SMECE) of the thyroid is an extremely rare tumor that exhibits unique histologic characteristics and is nearly always associated with lymphocytic thyroiditis (LT). However, the cytomorphologic and clinicopathologic characteristics of SMECE have only been described in rare case reports.

Materials And Methods: Authors' institution laboratory information systems were searched for records of SMECE between 2012 and 2023.

Intratumoral extramedullary hematopoiesis in solitary fibrous tumor of the breast.

Extramedullary hematopoiesis (EMH) is most often associated with underlying hematologic disorders, such as myeloproliferative neoplasms and thalassemia. EMH in the setting of solitary fibrous tumor (SFT) is exceedingly rare, with only 3 cases reported to date in the English literature. Herein, we describe our experience with a unique case of SFT arising in the breast with intratumoral foci of EMH in a 57-year-old woman who presented with an incidentally found right axillary mass on routine screening mammography.

Fibroadenoma-like Lesion of the Vagina: A Description of 2 Cases of a Previously Unreported Entity.

We report 2 cases of a previously undescribed vaginal lesion, which we term "fibroadenoma-like lesion of the vagina" because of the close morphologic resemblance to breast fibroadenoma. Both lesions arose in the upper vagina and exhibited a biphasic appearance with benign epithelial and stromal elements. The glandular epithelium comprised a double layer of luminal and basal cells with focal squamous differentiation in 1 case.

Ovarian steroid cell tumor, not otherwise specified, associated with congenital adrenal hyperplasia: rare tumors of an endocrine disease.

Ovarian steroid cell tumors, not otherwise specified (OSCTs), are extremely rare and present a diagnostic challenge when evaluating an ovarian mass. We present a case of such a tumor in a patient with known Congenital Adrenal Hyperplasia (CAH), secondary to 21-hydroxylase deficiency, who was noncompliant with her medications. The workup, diagnosis, and treatment of this rare condition are described.

The utility of PAX8 and IMP3 immunohistochemical stains in the differential diagnosis of benign, premalignant, and malignant endocervical glandular lesions.

Unlabelled: Glandular lesions of the endocervix can be diagnostically challenging and occasionally the differential diagnosis includes endocervical adenocarcinoma in situ (EC AIS) and well-differentiated endocervical adenocarcinoma (ECA). PAX8 and IMP3 are two markers which have not been well studied in the endocervix. Our aim was to evaluate their immunohistochemical (IHC) expression in benign and malignant endocervical glandular lesions as well as to compare them to the traditionally used panel (Ki-67, p16, CEA).

Prevalence of high-risk cervical human papillomavirus and squamous intraepithelial lesion in Nigeria.

Objective: The prevalence of cervical cancer and high-risk human papillomavirus (HPV) in Nigerian women remains poorly studied. Our objective was to estimate the prevalence of high-risk HPV and associated squamous intraepithelial lesions (SILs) in Nigeria.

Methods: After institutional review board approval, data collection was performed by volunteers of FaithCare, Inc, between 2004 and 2008 in 3 regions of Nigeria (Okene, Katari, and Abuja).

Atypical glandular cells on cervical cytology and breast disease: what is the association?

Objective: To determine whether metastatic mammary carcinoma can be detected on cervical cytology in patients with atypical glandular cells (AGCs).

Methods: This blinded study of AGC cases with a matched control group was approved by Hartford Hospital institutional review board. Between January 2002 and November 2008, inclusive, all Pap tests in our database with AGC were identified.

Epithelioid angiosarcoma: a brief diagnostic review and differential diagnosis.

Epithelioid angiosarcoma is a highly aggressive endothelial cell malignancy, most commonly arising in the deep soft tissues, but a variety of primary sites, including the adrenals, thyroid, skin, and bone, are encountered. On hematoxylin-eosin-stained sections, the pathologist encounters sheets of large, mildly to moderately pleomorphic epithelioid cells, with abundant eosinophilic cytoplasm, vesicular nuclei, and prominent nucleoli. Obvious vasoformative foci may not be present, creating confusion with metastatic carcinomas, malignant mesothelioma, melanoma, anaplastic lymphoma, epithelioid peripheral nerve sheath malignancies, and epithelioid sarcoma.

Crash patterns and potential engineering countermeasures at Maryland roundabouts.

Objectives: Each year in the United States more than 1.2 million injuries and 9,000 deaths occur in motor vehicle crashes at intersections. Previous research has found that construction of roundabouts in place of traditional intersections can decrease crash frequency and severity.

Prevalence of the human papillomavirus in an inner-city indigent population with previously normal Pap tests.

Objective: To determine the prevalence of human papillomavirus (HPV) in our inner-city indigent population (clinic population) of women with previously normal Pap tests and to identify any associated risk factors.

Materials And Methods: A prospective cohort of 187 women between the ages of 15 and 49 years, with previously normal Pap tests, was recruited from a university affiliated outpatient clinic. A demographic questionnaire of social and sexual history was elicited, and ThinPrep cytology (Cytyc, Marlborough, MA) and HPV Digene Hybrid Capture II results (Digine, Gaithersburg, MD) were obtained.

The prevalence of cervical HPV and cytological abnormalities in association with reproductive factors of rural Nigerian women.

Objective: To estimate the prevalence of cervical human papillomavirus (HPV) and cytological abnormalities while addressing demographic and reproductive variables in a sample of rural Nigerian patients.

Methods: In March 2004, a medical project was conducted in Okene, Nigeria. The obstetrics/gynecology team collected demographics of 231 patients and 199 ThinPrep Pap smears (Cytyc, Marlborough, MA), which were analyzed cytologically and for the presence of HPV DNA.

Dysplasia and malignancy in endocervical polyps.

Objective: The objective was to estimate the prevalence of malignancy or dysplasia in cervical polyps.

Methods: A convenience sample was identified by retrospectively searching the Hartford Hospital pathology database for cases of endocervical polyps removed from January 1, 1999, through January 31, 2006. The presence of malignancy, dysplasia, atypia, and other modifiers was recorded along with demographic information, including age, race/ethnicity, residence, and the ordering practitioner.

Temporal patterns of crashes of 16-to 17-year-old drivers in Fairfax County, Virginia.

Objective: To develop a better understanding of the frequency and characteristics of teenage driver crashes occurring during school commute times.

Method: Data were obtained from police reports of crashes involving drivers ages 16-17 that occurred between September 2001 and August 2004 in Fairfax County, Virginia. Temporal patterns and other characteristics of crash involvement during the school year were examined, and crashes during school commute times were compared with those at other times.

Diagnostic utility of D2-40 and podoplanin in effusion cell blocks.

The distinction between malignant mesothelioma and adenocarcinoma is a diagnostic challenge in cytologic specimens of effusion fluids. As for today, no single antibody has demonstrated absolute sensitivity or specificity for Mesothelioma. D2-40 and podoplanin have recently been recognized to stain mesothelial cells.

Lack of adherence to practice guidelines for women with atypical glandular cells on cervical cytology.

Objective: We sought to estimate the rates and types of evaluation in women with atypical glandular cells of undetermined significance (AGC-US) on cervical cytology and to assess these findings on the basis of published management guidelines.

Methods: The rates of histologic sampling, comprehensive initial evaluations, and secondary evaluations were assessed in 477 women with an AGC-US Pap test from 1998 to 2001. A comprehensive evaluation was defined as a colposcopy and an endocervical curettage with or without a cervical biopsy.

Dysplasia associated with atypical glandular cells on cervical cytology.

Objectives: To estimate the rates of and identify risk factors for disease in women with atypical glandular cells of undetermined significance (AGUS).

Methods: From 1998-2001, 477 Pap tests at Hartford Hospital were classified as AGUS and met the inclusion criteria of this study. Findings were evaluated for 2 years from the initial test.

Transitional cell carcinoma presenting as clitoral priapism.

Background: Clitoral priapism is an uncommon cause of clitoromegaly. It should be suspected in the absence of hirsuitism and the presence of clitoral engorgement, pain, and local irritation.

Case: A 48-year-old female had a straight catheterization of her bladder for a history of frequent urinary tract infections.

CD34-reactive trichodiscoma.

Background: Trichodiscomas are rare hamartomas of the dermal portion of the hair disc, a specialized component of the perifollicular mesenchyme. They are usually found as asymptomatic multiple skin-colored papules on the face and extremities and may have an autosomal dominant inheritance pattern. However, a solitary variant has been described.

Invasive mammary carcinoma after immediate and short-term follow-up for lobular neoplasia on core biopsy.

Lobular neoplasia (LN), including atypical lobular hyperplasia (ALH) and lobular carcinoma in situ, may be encountered in breast core biopsies performed for mammographic abnormalities even though LN is often not, in itself, responsible for the abnormal mammogram. The need for surgical excision following a diagnosis of LN on core biopsy is not well defined. We examined pathologic and mammographic findings in a consecutive series of cases diagnosed as LN to address this issue.

The use of lamellar body counts to predict fetal lung maturity in pregnancies complicated by diabetes mellitus.

Objective: The purpose of this study was (1) to correlate amniotic fluid lamellar body counts with the lecithin/sphingomyelin ratio and the presence of phosphatidylglycerol in pregnancies that were complicated by maternal diabetes mellitus and (2) to determine a lamellar body count value that maximizes sensitivity and specificity in the prediction of fetal lung maturity.

Study Design: We reviewed our prospectively collected perinatal database from November 1992 through October 1999 to identify pregnancies that were complicated by diabetes mellitus for which fetal lung maturity studies had been performed within 72 hours of delivery. Lamellar body counts were correlated with lecithin-sphingomyelin ratio and phosphatidylglycerol values.