Publications by authors named "Srinidhi Ganesamoorthi"
Bone tissue engineering (BTE) offers promising strategies for bone regeneration, yet the effective delivery of bioactive molecules remains a challenge. Khellin (KH), a plant-derived furanochromone, possesses various biological properties, though its potential in promoting osteogenesis has not been thoroughly investigated. In this study, 3D-printed polylactic acid (PLA) scaffolds were integrated with KH-loaded chitosan-alginate sponges (PLA/ALG/CS-KH) to facilitate controlled and sustained delivery of KH.
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- Critical-sized bone defects pose significant healthcare challenges, leading to the need for innovative approaches like bone tissue engineering (BTE).
- Surface engineering of bone scaffolds is essential in BTE, using natural polymers to create a bone-like microenvironment that improves cell functions such as adhesion and growth.
- The review details various surface modification techniques for different scaffold materials and discusses their effectiveness in enhancing bone regeneration, along with current research and future directions.
Non-coding RNA (ncRNA)-based therapies entail delivering ncRNAs to cells to regulate gene expression and produce proteins that combat infections, cancer, neurological diseases, and bone abnormalities. Nevertheless, the therapeutic potential of these ncRNAs has been limited due to the difficulties in delivering them to specific cellular targets within the body. Chitosan (CS), a biocompatible cationic polymer, interacts with negatively charged RNA molecules to form stable complexes.
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