Publications by authors named "Srilatha Reddy Gantala"
Introduction: Proprotein convertase subtilisin/kexin type 9 (PCSK9) genetic polymorphisms play a significant role in cholesterol homeostasis. Therefore, we aimed to investigate the association of PCSK9 genetic variations NM_174936.3:c.
View Article and Find Full Text PDFCollagenase-1 (-1607 1G/2G), Gelatinase-A (-1306 C/T), Stromelysin-1 (-1171 5A/6A) functional promoter polymorphisms in risk prediction of type 2 diabetic nephropathy.
Srilatha Reddy Gantala Mrudula Spurthi Kondapalli Ramanjaneyulu Kummari Chiranjeevi Padala Mohini Aiyengar Tupurani
Gene
October 2018
Type 2 Diabetic Nephropathy (DN) is a common multifactorial disorder. Degradation of glomerular basement membrane (GBM) by matrix metalloproteases (MMPs) is a key event in the progression of renal disease. A functional polymorphism at position -1607 1G/2G, -1306 C/T and -1171 5A/6A has been shown to alter the transcriptional activity of MMP-1, MMP-2, and MMP-3 respectively, and also associated with several diseases contributing to inter-individual differences in susceptibility to type 2 DN.
View Article and Find Full Text PDFArticle Synopsis
- * The study analyzes polymorphisms in CASP8 and CASP3 genes among 300 CAD patients and 300 healthy controls, using genetic testing methods to identify variations linked to disease risk.
- * Findings indicate that certain genotypes of CASP8 and CASP3 are associated with an increased risk of CAD, suggesting these polymorphisms could serve as genetic markers for the disease.