Publications by authors named "Srilatha Marate"
Acute encephalitis syndrome (AES) presents with the onset of fever, altered sensorium and/or seizures, known to be caused by various infectious and non-infectious aetiological agents, among which viruses are the commonest. The severity of AES prompts rapid diagnosis, which is not met by time-consuming conventional diagnostic techniques. In this study, archived cerebrospinal fluid samples of laboratory-confirmed viral AES, an acute infectious condition and Guillain-Barré Syndrome (GBS), a post-infectious, autoimmune condition was assessed for soluble membrane attack complex (sMAC) using ELISA.
View Article and Find Full Text PDFAs a variant of Vaccinia virus, Buffalopox virus is known to cause Buffalopox disease. In recent times, sporadic outbreaks of the infection in humans have been reported, especially in the endemic countries of Southeast Asia. Though mortality has not been high, associated morbidity is significant.
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- Acute encephalitis syndrome (AES) in children is a major health issue in India, and this study evaluates the role of inflammatory mediators and neurofilament (NfL) levels in differentiating the causes, understanding disease severity, and predicting outcomes in AES.* -
- The research analyzed serum and cerebrospinal fluid (CSF) samples from 62 children with AES, finding that markers differed significantly among scrub typhus, viral infections, and COVID-related multisystem inflammatory syndrome (MIS-C), with specific levels of cytokines revealing patterns that aid in diagnosis.* -
- The study concluded that certain serum markers could effectively differentiate between scrub typhus and other types of AES, and higher levels of certain
Guillain-Barré Syndrome (GBS) is an autoimmune neuropathy. Antecedent infections have been seen to be significant triggering factors for developing GBS. Among them, arboviral infections are rapidly gaining importance as significant triggers, especially in the areas where they are endemic.
View Article and Find Full Text PDFSARS-CoV-2 infection frequently causes neurological impairment in both adults and children. Recent publications have described significant aspects of the viral pathophysiology associated with neurological dysfunction. In theory, neurological manifestations following SARS-CoV-2 infection may be caused directly by the effects of the virus infecting the brain or indirectly by the local and systemic immune responses against the virus.
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- - Scrub typhus, caused by Orientia tsutsugamushi, is recognized as a significant contributor to acute encephalitis syndrome (AES) in northern India, and this study examined its impact in southern India by diagnosing 376 children with AES.
- - Among the children tested, scrub typhus was diagnosed in 87 (23%), with varying degrees of association to AES: confirmed in 16, probable in 55, and possible in 16 cases.
- - The study found that IgM detection in cerebrospinal fluid (CSF) is a reliable diagnostic tool, showing a 93% sensitivity and an 82% specificity, underscoring the need for routine testing for scrub typh
Background: Human metapneumovirus (HMPV) belongs to the family Pneumoviridae. It is one of the emerging respiratory viruses causing both upper and lower respiratory tract illnesses. HMPV has two genotypes: A and B.
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