Publications by authors named "Srikanth Kumar Karumanchi"
Objective: The objective of this study is to investigate the effects of an ethanolic extract derived from Agaricus subrufescens on rat models exhibiting Polycystic Ovarian Syndrome (PCOS) induced by Letrozole.
Methods: A total of thirty female Wistar rats were divided into five groups, each consisting of six rats. The negative control group was administered a volume of 1 mL of a 0.
Unveiling the Cardioprotective Power: Liquid Chromatography-Mass Spectrometry (LC-MS)-Analyzed (Roxb.) Bosser Leaf Ethanolic Extract against Myocardial Infarction in Rats and In Silico Support Analysis.
Plants (Basel)
October 2023
Article Synopsis
- * Using advanced techniques, researchers identified 32 active compounds from the leaf extract, which included two that showed strong potential for treating heart conditions, as indicated by their binding energies compared to the known medication atorvastatin.
- * In tests on rats with induced heart issues, the NCEE (leaf extract) treatment resulted in significant improvements, including reduced heart damage markers, enhanced antioxidant levels in heart tissue, and ECG results that were similar to those of rats treated with atorvastatin.
Objectives: The aim was the synthesis of novel substituted 5-[morpholino(phenyl)methyl]-thiazolidine-2,4-diones and screening for their hypoglycemic activity and anti-inflammatory activity, as well as molecular docking studies to find out active potential lead molecules.
Materials And Methods: Substituted aromatic aldehydes, thiazolidine-2,4-dione, and morpholine on Mannich reaction gave the title compounds. They were characterized by physical and spectral methods.