Publications by authors named "Srijana Davuluri"
Article Synopsis
- Lipodermatosclerosis (LDS) is related to vascular issues and skin inflammation, similar to systemic sclerosis (SSc), but its link to SSc hasn't been thoroughly explored in research.
- A study analyzed over 500 patients with SSc to determine how common LDS is and its relationship with severe complications like pulmonary hypertension.
- Results showed that LDS was present in 4.4% of SSc patients, and those with LDS had significantly higher rates of cardiac arrhythmias, heart failure, and pulmonary hypertension compared to those without LDS.
Purpose Of Review: To provide the most recent literature on our understanding behind the pathogenesis and the treatment of calcinosis in dermatomyositis.
Recent Findings: Early diagnosis and controlling the overall disease activity are cornerstones to prevent calcinosis in juvenile dermatomyositis. Observational cohort studies showed that prolonged state of inflammation and features of vascular dysfunction like digital ulcers and abnormal nailfold capillaries are associated with calcinosis.
Purpose Of Review: To provide updated information on the prevalence, pathogenesis, diagnostics, and therapeutics of calcinosis cutis associated with systemic sclerosis (SSc).
Recent Findings: Observational studies show ethnic and geographical differences in the prevalence of calcinosis. In addition to clinical and serological associations, biochemical studies and in-vivo models have attempted to explain theories behind its pathogenesis, including prolonged state of inflammation, mechanical stress, hypoxia, and dysregulation in bone and phosphate metabolism.
Purpose Of Review: The aim of this study was to provide updated information on the prevalence, pathogenesis, diagnostics and therapeutics of calcinosis cutis associated with systemic sclerosis (SSc).
Recent Findings: Observational studies show ethnic and geographical differences in the prevalence of calcinosis. In addition to clinical and serological associations, biochemical studies and in-vivo models have attempted to explain theories behind its pathogenesis, including prolonged state of inflammation, mechanical stress, hypoxia and dysregulation in bone and phosphate metabolism.
Calcinosis in dermatomyositis: Origins and possible therapeutic avenues.
Best Pract Res Clin Rheumatol
June 2022
Calcinosis, insoluble calcium compounds deposited in skin and other tissues, is a crippling sequela of dermatomyositis. Prolonged disease associated with ongoing inflammation, ischemia, repetitive trauma, and certain autoantibodies are associated with calcinosis. Herein, we describe potential pathogenic mechanisms including the role of mitochondrial calcification.
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