A putative stem-loop structure in is required for mRNA localisation in epithelia and germline cells.

Crumbs (Crb) is an evolutionarily conserved transmembrane protein localised to the apical membrane of epithelial cells. Loss or mislocalisation of Crb is often associated with disruption of apicobasal cell polarity. mRNA is also apically enriched in epithelial cells, and, as shown here, accumulates in the oocyte of developing egg chambers.