Publications by authors named "Sridhar M Veluvolu"
Purpose: The importance of cellular context to the synergy of DNA damage response (DDR)-targeted agents is important for tumors with mutations in DDR pathways, but less well-established for tumors driven by oncogenic transcription factors. In this study, we exploit the widespread transcriptional dysregulation of the EWS-FLI1 transcription factor to identify an effective DDR-targeted combination therapy for Ewing sarcoma.
Experimental Design: We used matrix drug screening to evaluate synergy between a DNA-PK inhibitor (M9831) or an ATR inhibitor (berzosertib) and chemotherapy.
Purpose Of Review: The purpose of this review is to describe key pharmacologic considerations to inform strategies in drug development for pediatric cancer.
Recent Findings: Main themes that will be discussed include considering patient specific factors, epigenetic/genetic tumor context, and drug schedule when optimizing protocols to treat pediatric cancers.
Summary: Considering these factors will allow us to more effectively translate novel targeted therapies to benefit pediatric patients.
Background: While rare, multiple individual case reports have described mixed thyroid tumours in dogs containing both epithelial and mesenchymal neoplastic components.
Objectives: In this retrospective case series, we describe the clinical presentation, treatment and outcome of 14 dogs of canine thyroid tumours with concurrent mesenchymal and epithelial neoplastic populations.
Methods: Fourteen cases were retrospectively abstracted from nine institutions.
Article Synopsis
- - A 3-year-old dog at UC-Davis had nosebleeds and swollen lymph nodes for a year, with a history of skin allergies, but no travel outside California.
- - Blood tests showed abnormal protein levels, and a bone marrow biopsy revealed Leishmania infantum, confirming the first case of canine leishmaniasis in California.
- - It is believed the dog was infected from its Serbian mother; hence, dog owners should be cautious about getting puppies from areas where leishmaniasis is common to reduce the risk of spreading it.
Olfactory neuroblastoma (ONB) is a rare intranasal neoplasm in both dogs and humans. Similar clinical presentation and overlapping histologic and immunohistochemical features of ONB with other intranasal neoplasms can make diagnosis and treatment of intranasal neoplasia challenging. Furthermore, in part because of their rarity, there is a lack of reporting on therapeutic regimen for these neoplasms.
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- The study aimed to assess the safety and effectiveness of MOPP chemotherapy for treating cats with relapsed or refractory lymphoma.
- Out of 38 cats treated, 70.3% responded to the chemotherapy, with a median remission duration of 166 days and some cats maintaining response for up to a year.
- Common side effects included neutropenia and gastrointestinal upset, but 55.3% of cats experienced no adverse effects, suggesting that MOPP is a relatively safe treatment option.