Publications by authors named "Sridevi Vallabu"
Podocytes are an integral and important constituent of the glomerular filtration barrier (GFB) and are exposed to a higher concentrations of ANG II in diseased states; consequently, podocytes may accumulate oxidized proteins and damaged mitochondria. In the present study, we evaluated the effect of ANG II on the podocyte autophagic process, which is likely to be triggered in order to degrade unwanted proteins and damaged organelles. To quantitate the occurrence of autophagy, electron microscopic studies were carried out on control and ANG II-treated conditionally immortalized mouse podocytes (CIMPs).
View Article and Find Full Text PDFHIVAN phenotype: consequence of epithelial mesenchymal transdifferentiation.
Am J Physiol Renal Physiol
March 2010
Article Synopsis
- HIV-1-associated nephropathy (HIVAN) involves changes in kidney cells, specifically the growth of glomerular and tubular epithelial cells, influenced by epithelial mesenchymal transdifferentiation (EMT).
- Researchers used mouse models to study these changes, finding that certain kidney cells (PGCs and PTCs) showed characteristics of myofibroblasts and that EMT was marked by reduced E-cadherin expression.
- Blocking the AT1 receptor with telmisartan in Tg26 mice led to a significant decrease in proliferation and EMT marker expression, suggesting that targeting this pathway may help manage HIVAN.