Publications by authors named "Sri Suryanti"
Renal cell carcinoma occurrence is increasing from time to time and known as one of the most common cancers worldwide. RCC usually found in older age and common acquired risk factors for RCC including obesity, hypertension, diabetes, smoking and long-term use of NSAIDs. As for genetic risk, it is noted that Von Hippel-Lindau gene involved in the pathogenesis of RCC.
View Article and Find Full Text PDFCD103+ T Lymphocyte Count Linked to the Thickness of Invasion on Acral Melanoma without E-Cadherin Involvement.
Clin Cosmet Investig Dermatol
November 2021
Article Synopsis
- - Acral melanoma (AM) is an aggressive skin cancer found in areas of the body that don't get sun exposure, and E-cadherin and CD103 are both markers related to its invasion and progression, though E-cadherin's role in AM is not well understood.
- - This research aimed to examine the relationship between E-cadherin and CD103 immunoexpression and the thickness of invasion in 40 AM tissue samples, using a Chi-Square test to analyze the data.
- - Results showed no significant link between E-cadherin and invasion thickness (p = 0.4272), while CD103 exhibited a significant association (p = 0.0001), suggesting that CD103 might
Article Synopsis
- Clear cell renal cell carcinoma (ccRCC) is a highly lethal urinary tract cancer that is resistant to standard treatments, with a low survival rate when metastasis occurs.
- The study focuses on the role of cyclooxygenase-2 (COX-2), an inflammatory protein, and programmed death ligand-1 (PD-L1) in the metastasis of ccRCC.
- Results indicate a significant link between high COX-2 levels and increased metastases, while PD-L1 levels had no significant association with metastasis or with COX-2 expression.
Article Synopsis
- The study evaluated the impact of different fixation durations in 96% alcohol on protein preservation for immunohistochemistry compared to the standard 10% neutral buffered formalin (NBF).
- Researchers used 25 carcinoma specimens, fixing them in both solutions for various timeframes (1, 6, 24, 48, and 72 hours) and performed cell block preparation to assess E-cadherin and Ki67 expression.
- Results showed significant differences in protein expression between 96% alcohol and NBF, concluding that 96% alcohol is not an appropriate fixative for preparing samples for E-cadherin and Ki67 evaluation.
This is the first recorded case of urinary tract villous adenoma in Indonesia. A 70-years-old man suffered from a painful left flank mass and jelly like mixed urine. He had undergone percutaneous nephrostomy yielding a jelly like substance, and a previous stone surgery.
View Article and Find Full Text PDFThe Correlation of Gene Expression and Immunoexpression in Colorectal Adenocarcinoma.
Open Access Maced J Med Sci
June 2019
Background: Colorectal Adenocarcinoma (ADCCR) is the third most cancer not only in the world but also in Indonesia. There were 623 cases of ADCCR at Dr Hasan Sadikin hospital within 2015-2017. Both KRAS and TP53 mutation are known as genes which involve in carcinogenesis through the same pathway, namely the chromosomal instability pathway.
View Article and Find Full Text PDFCorrelation between EGFR Expression and Radiosensitivity in Cervical Adenocarcinoma Cases.
Asian Pac J Cancer Prev
January 2017
Background: Most of the cervical cancer patients, including those with cervical adenocarcinomas, come at advanced stage in the developing world so its mortality is high. Radiotherapy is one of the treatment modality for advanced stage cervical adenocarcinomas, but its efficacy depends on several prognostic factors such as the stage, histopathology, presence of organ dysfunction and expression of cellular biology markers mainly involve in cell proliferation such as the epidermal growth factor receptor (EGFR). Some research indicates that activation of EGFR in malignancy (including cervical cancer) correlates with aggressive behavior, a poor prognosis and decreasing sensitivity of radiotherapy.
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