Publications by authors named "Sri Mutya Sekarutami"
Background: ALDH1 is a cervical cancer stem cell marker that has radioresistance profile. Recurrence and metastasis following radiotherapy are still being problems of most patients. This study aimed to determine the correlation between ALDH1 and radiotherapy response in stage III squamous cell cervical carcinoma (SCCC) of the cervix.
View Article and Find Full Text PDFIntroduction: Nasopharyngeal cancer in Indonesia has a poor survival rate and there is only few studies regarding nasopharyngeal cancer in Indonesia. Therefore, this study was made to present Indonesian nasopharyngeal cancer data with special focus on survival of nasopharyngeal cancer profile that receives radiation therapy.
Methods: This was a retrospective study conducted in the Department of Radiation Oncology, Dr.
Article Synopsis
- Cancer stem cells, particularly transcription factors SOX2 and OCT4, are linked to radioresistant cancers and contribute to treatment challenges in cervical cancer.
- A study of 40 patients with stage IIIB cervical squamous cell carcinoma found that high levels of SOX2 and OCT4 were associated with incomplete responses to radiotherapy.
- These findings suggest that measuring SOX2 and OCT4 expression could help predict treatment outcomes in cervical cancer patients undergoing radiotherapy.
Objective: Chemoradiation is the standard therapy for advanced stages of cervical cancer. In developing countries, where 80% of cervical cancers occur, this is not always available. Carbogen breathing and oral nicotinamide (CON) therapy, aimed at overcoming tumor hypoxia, has shown to improve treatment efficacy in some epithelial tumors.
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