Publications by authors named "Sreyashi Majumdar"
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent of coronavirus induced disease-2019 (COVID-19), is a type of common cold virus responsible for a global pandemic which requires immediate measures for its containment. India has the world's largest population aged between 10 and 40 years. At the same time, India has a large number of individuals with diabetes, hypertension and kidney diseases, who are at a high risk of developing COVID-19.
View Article and Find Full Text PDFBackground: The pathobiology of atopic asthma is complex and the symptoms similar to other respiratory diseases. As such, identification of biomarkers of atopic asthma is of prime importance for better diagnosis and control of the disease.
Objectives: We sought to study the changes in plasma proteome and cytokine-expression profile across healthy and atopic asthmatics for identifying biomarkers and exploring aberrant pathways for atopic asthma.
Article Synopsis
- Asthma is a complex condition divided into atopic (related to allergies) and non-atopic types, and treatments include monoclonal antibodies (MAbs) that target specific interleukins (ILs) involved in airway inflammation.
- *Currently, only a few MAbs have received FDA approval, while others are still in clinical trials, and small chemical modulators targeting ILs and their receptors are being researched as a potentially more accessible treatment option.
- *Computational tools are being utilized to identify effective small chemical modulators for atopic asthma, particularly focusing on IL-33, to complement existing MAb therapies and improve treatment options.