Indian J Otolaryngol Head Neck Surg
December 2022
While a comprehensive booth audiogram is the gold standard for diagnosis of hearing loss, access to this may not be available in remote and low resource settings. The aims of this study were to validate a tablet-based audiometer in a tertiary medical center in India and explore its capacity in improving access to hearing healthcare. Subjects presenting to Ear-Nose-Throat clinics for conventional booth audiometry testing were recruited for subsequent tablet-based audiometric testing.
View Article and Find Full Text PDFAnn Otol Rhinol Laryngol
September 2021
Objectives: Obstructive sleep apnea (OSA) is characterized by repeated upper airway collapse while sleeping which leads to intermittent hypoxemia. Upper airway stimulation (UAS) is a commonly practiced modality for treating OSA in patients who cannot tolerate, or do not benefit from, positive airway pressure (PAP). The purpose of this study is to identify the effect of lateral pharyngeal collapse patterns on therapy response in UAS.
View Article and Find Full Text PDFJAMA Facial Plast Surg
January 2019
This study compared preoperative and postoperative photographs of patients who underwent nasal reconstruction with paramedian forehead flaps to analyze differences in eyebrow position.
View Article and Find Full Text PDFParathyroid glands undergo a variable descent during embryologic development and can be found anywhere in the neck from the level of the mandible to the mediastinum. To the best of our knowledge, we present the first report of a patient who was found to have bilateral parathyroid adenomas in her pyriform sinuses. A middle-aged woman with renal failure and secondary hyperparathyroidism presented with dysphagia and was found to have bilateral pyriform sinus masses on endoscopy.
View Article and Find Full Text PDFRadiation-induced fibrosis (RIF) is a major side effect of radiotherapy in cancer patients with no effective therapeutic options. RIF involves excess deposition and aberrant remodeling of the extracellular matrix (ECM) leading to stiffness in tissues and organ failure. Development of preclinical models of RIF is crucial to elucidate the molecular mechanisms regulating fibrosis and to develop therapeutic approaches.
View Article and Find Full Text PDFInt Forum Allergy Rhinol
October 2017
Background: Juvenile nasopharyngeal angiofibroma (JNA) is a benign tumor that presents in adolescent males. Although surgical excision is the mainstay of treatment, recurrences complicate treatment. There is a need to develop less invasive approaches for management.
View Article and Find Full Text PDFObjectives/hypothesis: This feasibility study was designed to show the preliminary safety and efficacy of targeted hypoglossal neurostimulation (THN), and to identify baseline predictors of successful therapy.
Study Design: Open-label, prospective, multicenter, single-arm cohort study, conducted at seven centers in the U.S.
Objectives/hypothesis: Determine the impact of nasal obstruction on efficacy, success, and adherence of Provent therapy in patients with obstructive sleep apnea (OSA).
Study Design: Prospective, two-arm, clinical pilot study at a single clinical site.
Methods: Patients with OSA who failed continuous positive airway pressure therapy were divided into two treatment arms: arm 1 were patients with no complaints of nasal obstruction and <50% nasal obstruction on exam, and arm 2 were patients with occasional complaints of nasal obstruction and 50% to 80% nasal obstruction on exam.
Objective: To identify factors that may be associated with lingual tonsil hypertrophy (LTH).
Study Design: Case series with chart review.
Setting: Tertiary academic center.
Otolaryngol Head Neck Surg
April 2015
Objective: Comparisons among studies involving the tongue base are limited by lack of a universal system for grading lingual tonsils. The authors propose a new standardized clinical grading system for lingual tonsil hypertrophy (LTH). Validation was assessed via an interexaminer agreement study.
View Article and Find Full Text PDFObjectives/hypothesis: To determine the effect of treatment of obstructive sleep apnea (OSA) with custom-made mandibular advancement devices (MADs) on C-reactive protein (CRP) levels in patients with obstructive sleep apnea/hypopnea syndrome (OSAHS).
Study Design: Case series with chart review.
Methods: Charts of consecutive patients fitted with custom-made mandibular advancement devices for treatment of OSAHS between December 2011 and November 2012 were reviewed.
Objectives: To evaluate the impact of combined nasal surgery and endoscopic sinus surgery on the objective measurements of obstructive sleep apnea (OSA) and sleep architecture by comparing polysomnographic data before and after combined surgery in patients with OSA.
Study Design: Case series with chart review.
Setting: A single clinical site.
Objective: To determine the effect of twice-daily proton pump inhibitor (PPI) treatment on the relationship between laryngopharyngeal pH environment and symptoms in patients with laryngopharyngeal reflux (LPR).
Study Design And Setting: Retrospective analysis of records from consecutive patients seen at a single clinical site between 2009 and 2012.
Subjects And Methods: Forty-three records of patients diagnosed with LPR who underwent pre- and posttreatment pH studies were included.
Objectives: To investigate the safety and outcomes of Z-palatopharyngoplasty (ZPPP) combined with endoscopic Coblator open tongue base resection (Eco-TBR) for the treatment of severe obstructive sleep apnea/hypopnea syndrome (OSAHS).
Study Design: Review of a prospective database.
Setting: Academic tertiary medical center.
The objective of this study was to evaluate the relationship between subjective and objective tonsil size measurements in adult patients with obstructive sleep apnea/hypopnea syndrome (OSAHS) and compare the tonsil size measurements with the severity of disease. Fifty-one adult patients (46 males and 5 females) who failed continuous positive airway pressure therapy and underwent OSAHS surgery were recruited. Physical examinations, subjective tonsil size grading preoperatively, and objective tonsil measurements including size (length, width, and height), weight and volume immediately after surgery were recorded.
View Article and Find Full Text PDFJAMA Otolaryngol Head Neck Surg
January 2014
Importance: This study provides insight into the response and cure rates of oral appliances (OAs) in patients with primary retropalatal, retroglossal, or retroepiglottic obstruction, as well as the effect of minimal cross-sectional area on the overall decrease in the apnea-hypopnea index (AHI) across all anatomical locations of collapse.
Objective: To examine the role of regional upper airway obstruction measured with acoustic pharyngometry as a determinant of OA success.
Design, Setting, And Participants: This retrospective case-series included patients with obstructive sleep apnea-hypopnea syndrome at a tertiary care center.
JAMA Otolaryngol Head Neck Surg
December 2013
Importance: Efficient diagnosis and early treatment of obstructive sleep apnea may help prevent the development of related morbidity and mortality. Compared with polysomnography (PSG), ambulatory sleep study devices offer the possibility of an accurate diagnosis with convenience and low cost.
Objective: To assess the correlation between sleep indexes measured by a portable sleep-testing device (peripheral arterial tonometry [PAT]) and those measured by PSG.