Evaluation of an AI Model to Assess Future Breast Cancer Risk.

Background Accurate breast cancer risk assessment after a negative screening result could enable better strategies for early detection. Purpose To evaluate a deep learning algorithm for risk assessment based on digital mammograms. Materials and Methods A retrospective observational matched case-control study was designed using the OPTIMAM Mammography Image Database from the National Health Service Breast Screening Programme in the United Kingdom from February 2010 to September 2019.

Insight into OroxylinA-7--β-d-Glucuronide-Enriched Bark Extract in Oral Cancer HSC-3 Cell Apoptotic Mechanism: Role of Mitochondrial Microenvironment.

, of the Bignoniaceae family, has various ethnomedical uses such as an astringent, anti-inflammatory, anti-bronchitis, anti-helminthic and anti-microbial, including anticancer properties. The druggability of OI stem bark extract was determined by its molecular docking interactions with PARP and Caspase-3, two proteins involved in cell survival and death. Note that 50 µg/mL of extract (OIE) showed a significant ( < 0.

Neonatal and infantile spinal sonography: A useful investigation often underutilized.

Sonography is an ideal, effective, noninvasive tool for evaluation of the spinal cord in neonatal and early infantile age groups owing to lack of ossification of the posterior elements of spine. Understanding normal anatomical appearances is a prerequisite for the interpretation of various pathologies of the spinal canal and its contents. This review elucidates normal appearances of the spinal cord in this age group, in both axial and sagittal planes.

Cranioplasty of Large Cranial Defects With Porous Polyethylene Implants.

Background: Reconstruction of cranial defects due to trauma or other causes has been carried out since ages with a wide variety of materials. The aim of reconstruction was mainly to restore cosmesis and protect the brain from further injury. However, recent studies have shown that cranioplasty not only improves the cerebral blood flow but also leads to improvement of cognitive functions.

Intracranial penetrating injury by screw driver: a case report and review of literature.

Penetrating injury to the head, with the exception of missile injuries is rare owing to thick calvarium. Orbital and temporal areas are comparatively vulnerable to penetrating injuries, due to their relative thinness. A case is presented in which a man killed his wife by forcefully thrusting a screw driver into her cranial cavity.

Sudden death in advanced abdominal pregnancy: a case report and discussion of the related medicolegal issues.

We report sudden unexpected death in a 35-year-old woman with pregnancy of seven months duration. There was an allegation by the parents of the woman that she was subjected to an assault prior to death. Autopsy examination showed an abdominal pregnancy with a dead fetus, ruptured gestational sac, massive haemorrhage and secondary placental attachment.

Post-traumatic cervical pneumorrhachis--a rare entity.

Pneumorrhachis(PR) is a rare phenomenon and post traumatic PR even more so. Presentation can vary from asymptomatic to significant neurological deficit and so the management has to be individualised. We present a case of post-traumatic cervical PR.

A practical total synthesis of (+)-spirolaxine methyl ether.

An efficient and practical total synthesis of (+)-spirolaxine methyl ether is described. The phthalide-aldehyde 3 has been prepared via the Diels-Alder reaction between 1,4-unconjugated diene 5 and a long-chain acetylenic dienophile 6. The carbon framework of spiroketal sulfone 4 has been constructed from monobenzyl protected 1,5-pentanediol and the stereochemistry in both the phthalide portion and the spiroketal portion has been established by the Sharpless asymmetric epoxidation.

A simple solution for reducing artefacts due to conductive and dielectric effects in clinical magnetic resonance imaging at 3T.

The quality of imaging obtained at high magnetic field strengths can be degraded by various artefacts due to conductive and dielectric effects, which leads to loss of signal. Various methods have been described and used to improve the quality of the image affected by such artefacts. In this article, we describe the construction and use of a simple solution that can be used to diminish artefacts due to conductive and dielectric effects in clinical imaging at 3T field strength and thereby improve the diagnostic quality of the images obtained.

Breast lesion analysis of shape technique: semiautomated vs. manual morphological description.

Purpose: To investigate the efficacy of an automated method of shape measurement for improving the discrimination of benign and malignant breast lesions.

Materials And Methods: A total of 47 breast lesions (32 malignant and 15 benign) were examined using a 1.5 Tesla system.

Diffusion-weighted imaging of normal and malignant prostate tissue at 3.0T.

Purpose: To measure the apparent diffusion coefficient (ADC) of normal and malignant prostate tissue at 3.0T using a phased-array coil and parallel imaging, and determine the utility of ADC values in differentiating tumor from normal peripheral zone (PZ).

Materials And Methods: ADC values were calculated for 49 patients (tumor and PZ) with evidence of prostate cancer.

Chronic haematoma or soft-tissue neoplasm? A diagnostic dilemma.

Chronic soft-tissue haematomas are infrequently reported in the literature. We present a case of a slowly expanding post-traumatic chronic soft-tissue haematoma located anterior to the knee and leg, occurring in a region previously unreported. Both clinically and radiologically, it was impossible to distinguish the haematoma from an aggressive soft-tissue neoplasm.

Timing of antibiotic prophylaxis in surgery for adult hip fracture.

Background: Antibiotic prophylaxis is widely used in surgery for hip fractures.

Methods And Results: In a retrospective study of case notes of 100 patients, frequent inaccuracies in dose administration were observed. This was applicable to both the pre-operative and the postoperative doses.

Role of fine needle aspiration cytology in the diagnosis of breast lumps and its histopathological correlation.

Lumps in breast may be due to benign or malignant lesions. Fine Needle Aspiration Cytology is a quick, simple and inexpensive procedure in diagnosis of these lesions. This helps the clinician in planning the correct surgical or medical treatment.