Publications by authors named "Sreekrishna Donepudi"
Body mass index as an indicator of obstructive sleep apnea in pediatric Down syndrome.
Int J Pediatr Otorhinolaryngol
July 2010
Objective: Our objective was to determine if higher body mass index (BMI) increases the likelihood of, obstructive sleep apnea (OSA) in pediatric Down syndrome (DS) patients.
Methods: We performed a, retrospective chart review of 63 DS patients evaluated by overnight polysomnography from December 1995 to February 2005. Patients aged less than 2 years were excluded.
Cleft palate lateral synechia syndrome: an opportunity for unique surgical closure.
Int J Pediatr Otorhinolaryngol
June 2009
Article Synopsis
- The study presents two cases of cleft palate lateral synechia (CPLS) syndrome in siblings from the same family, highlighting the surgical methods used for repair.
- Genetic analysis was performed, revealing no chromosomal defects or mutations in the IRF6 gene, while noting a pattern of autosomal dominant inheritance in the family.
- The results suggest that CPLS is a rare condition and emphasize the importance of understanding various diagnosis and treatment options in cleft palate surgeries, particularly as more otolaryngologists engage in such procedures.
Malignant infantile osteopetrosis (MIOP) is a rare disorder caused by dysfunctional osteoclasts. The classic MIOP features, such as frontal bossing, micrognathia, and small thorax, may place these children at risk for developing obstructive sleep apnea (OSA) and chronic hypoxemia. To objectively document OSA, airway evaluations were performed; results impacted management.
View Article and Find Full Text PDFAural involvement in loxoscelism: case report and literature review.
Int J Pediatr Otorhinolaryngol
November 2005
An 11-year-old male presented with fever, rash, and a necrotic lesion on the lobule of the left ear. The lesion became tender and formed an eschar over 4 days. The patient developed leukocytosis, hemolytic anemia, and proteinuria, and was diagnosed with systemic loxoscelism from a brown recluse spider bite.
View Article and Find Full Text PDFObjectives: Pediatric deep neck space abscesses are frequently treated by the otolaryngologist. We report four children with deep neck abscesses caused by methicillin-resistant Staphylococcus aureus (MRSA), including the first described case of descending mediastinitis caused by MRSA in a child.
Methods: Records from March 2001 to April 2002 were reviewed.
Chronic B cell malignancies are often chemoresistant and the development of new therapeutic modalities is a high priority. Many B cell malignancies have autocrine production of IL-10, which regulates B cell growth and differentiation. Here we demonstrate that the soy isoflavone genistein, a tyrosine kinase inhibitor, rapidly decreased IL-10 secretion followed by upregulation of IFNgamma and inhibition of cell proliferation with pre-dominantly G2 arrest.
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