Publications by authors named "Sreekar R Puchala"
Article Synopsis
- Immune checkpoint inhibitors (ICI) improve survival in non-small-cell lung cancer (NSCLC), but many patients eventually develop acquired resistance (AR), with underlying mechanisms largely unknown.
- The study analyzed tumor biopsies from 82 NSCLC patients who developed AR after ICI treatment, using techniques like genomic profiling and immunophenotyping, and compared them to control patients who received other treatments.
- Results showed that AR was linked to specific mutations in about 27.8% of patients, significant reductions in certain immune cells and HLA class I expression, pointing to the complex nature of resistance that must be addressed in future therapies.
