Publications by authors named "Sreedharan Nair Sabarinath"
Drug development continues to be time consuming, expensive and less efficient, while drug therapy is often administered at suboptimal levels. This is particularly true with anti-infectives for HIV and tuberculosis. The application of pharmacometric principles and models to drug development and pharmacotherapy will improve the drug approval process and selection of optimal dosage regimens or therapeutic combinations.
View Article and Find Full Text PDFLinezolid is the first FDA-approved oxazolidinone with activity against clinically important gram-positive pathogens, including methicillin (meticillin)-resistant Staphylococcus aureus (MRSA). RWJ-416457 is a new oxazolidinone with an antimicrobial spectrum similar to that of linezolid. The goal of the present study was to develop a general pharmacokinetic (PK)-pharmacodynamic (PD) model that allows the characterization and comparison of the in vitro activities of oxazolidinones, determined in time-kill curve experiments, against MRSA.
View Article and Find Full Text PDFCeftobiprole is a promising new broad-spectrum cephalosporin with activity against several multidrug-resistant gram-positive and gram-negative species, including methicillin-resistant Staphylococcus aureus. In order to make efficacy predications against these resistant bacteria in soft-tissue infections, i.e.
View Article and Find Full Text PDFExposure of inhaled corticosteroids (ICSs) in pediatrics results in adrenal suppression and growth inhibition. The objective of this study was to assess the relationship of ICS mediated growth retardation with cortisol suppression in asthmatic children. A meta-analysis approach was performed with 33 published articles.
View Article and Find Full Text PDFArticle Synopsis
- Prednisolone is used to treat inflammation and autoimmune diseases, with its effects influenced by the time of day due to nonlinear pharmacokinetics and circadian rhythms in biomarkers like cortisol and blood lymphocytes.
- The study aims to assess how the timing of prednisolone doses affects its pharmacokinetics and pharmacodynamics through simulation, finding that dosing in the early morning might lead to lower drug concentrations but can optimize therapeutic outcomes.
- Results highlight the importance of considering the timing (chronotherapy) and dosage of prednisolone for improved clinical effectiveness and reduced side effects, suggesting that a simulation approach is useful for understanding these time-dependent effects.