Covalent Functionalization of Organic Nanoparticles Using Aryl Diazonium Chemistry and Their Solvent-Dependent Self-Assembly.

A simple method for covalent functionalization of Fréchet-type dendron nanoparticles (FDNs) using tris-bipyridylruthenium(II) is described. Covalent functionalization is achieved by chemically reducing the diazo derivative of a ruthenium(II)bipyridine complex in the presence of FDNs wherein the radical species generated gets covalently linked to the nanoparticle surface. Simplicity, rapidity, and robustness are the advantages offered by the present approach.

Organic nanoparticles composed of Fréchet-type dendrons: synthesis, characterization, self-assembly and reversible guest encapsulation.

Novel organic nanoparticles composed of Fréchet-type dendrons have been synthesized by a simple one-pot reaction, which involved etching off the gold core in a first generation gold nanoparticle-cored dendrimer (AuG). Dissolution of the Au core leads to the generation of numerous dendron radicals in a small volume, which underwent very fast coupling and addition reactions to form the Fréchet-type dendron nanoparticles (FDNs). The FDNs were found to be nearly monodispersed with an average size of 3 nm.

Reversible action of diaminothiazoles in cancer cells is implicated by the induction of a fast conformational change of tubulin and suppression of microtubule dynamics.

Diaminothiazoles are novel cytotoxic compounds that have shown efficacy toward different cancer cell lines. They show potent antimitotic and antiangiogenic activity upon binding to the colchicine-binding site of tubulin. However, the mechanism of action of diaminothiazoles at the molecular level is not known.