Publications by authors named "Spyros Fotopoulos"
Article Synopsis
- Activin-A plays a significant role in neonatal infections, particularly in septicemic preterm and term neonates, by affecting inflammatory responses in their leukocytes.
- A study involving blood samples from septicemic neonates and healthy controls showed that activin-A levels were elevated in septicemic infants, with leukocytes being a major source of this cytokine.
- Treatment with activin-A led to reduced levels of pro-inflammatory cytokines while increasing the anti-inflammatory mediator IL-10, highlighting its potential as an immunomodulatory agent in managing inflammation in septicemic neonates.
During infections, pathogens bind to toll-like receptor (TLR)4 and CD14 receptors and induce cytokine release, leading to inflammation. Here, we investigated TLR4 and CD14 expression on peripheral blood leukocytes (PBLs) and their roles in lipopolysaccharide (LPS)-induced cytokine and chemokine release. Full-term and preterm neonates and adults were studied.
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- Homozygosity for the D409H mutation is linked to a severe type III disease characterized mainly by cardiovascular issues, with minimal neurological symptoms.
- Three patients (1 Greek, 2 Albanians) were identified to have both the D409H/D409H genotype and a severe early-onset neurological phenotype, classified as type II.
- The full coding region of the GBA gene showed these patients were homozygous for both D409H and H255Q mutations, with the double allele being present in other populations but absent in Spanish patients with D409H.
Aim: The inflammatory response induced by perinatal infections and asphyxia is considered to participate in neonatal brain damage. Inflammatory responses are characterized by the expression of chemokines. Although chemokine levels have been investigated in healthy newborns, their role during neonatal pathological conditions has not been studied.
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