[The systems principle in establishing the allowable human daily dose of pesticides].

Instead of the earlier isolated standardization of the levels of pesticides in the foodstuffs, water, air, a comprehensive hygienic regulation of pesticides in the environmental objects, which is based on the criterion--an allowable daily dose (ADD)--has been implemented since 1967. The systems principle is used, by taking into account the toxicological and hygienic parameters and the adverse reactions. Tens of thousands of regulations have been legally adopted.

[Principles and methods of the evaluation of occupational risks in the complex exposure to pesticides].

The authors suggested integral criterion for complex evaluation of pesticides variety and dose loads specific for the occupation. Therefore, pesticides could be classified according to toxicologic criteria and application conditions. Recommendations include management to minimize risk associated with pesticides.

Predicting pesticide residues to reduce crop contamination.

The system of dynamics between pesticides and plants is reviewed, and a conceptual model capable of reflecting the necessary qualitative and structural peculiarities is proposed as a means of predicting residue levels. The degradation processes of various chemical classes of pesticides in plants under different conditions of use are analyzed. Formulas are developed that enable recognition and estimation of residue levels and duration of retention for "new" pesticides and "old" substances under varying treatment conditions.

[Prediction of pesticide stability in plants based on experimental research data].

A hypothesis regarding the nature of interactions in the pesticide-plant system has been advanced and tested. The data obtained prompted the development of a calculation procedure which enables the determination of the number of pesticides at the preset moment of time, the prognosis of the period of complete disappearance of pesticides and the expectancy data on the basis of the physicochemical properties of pesticides, chemical features of the plants and the treatment conditions. This makes it possible to reveal and consider the most important factors implicated in the pollution even at the stage of preventive sanitary survey.

[Modeling calculations of pesticide contamination of horticultural products].

The growth of the pesticies production and of the scope of their use can produce in man and in his environment some adverse consequences, the elimination of which is possibly by their proper and safe management. In order to solve this problem it is necessary to elicit basic factors determining this process and also to foresee the outcome of it under changing conditions, i.e.