Assessment of Clinical Pharmacokinetic Drug-Drug Interaction of Antimalarial Drugs α/β-Arteether and Sulfadoxine-Pyrimethamine.

Antimalarial drug combination therapy is now being widely used for the treatment of uncomplicated malaria. The objective of the present study was to investigate the effects of coadministration of intramuscular α/β-arteether (α/β-AE) and oral sulfadoxine-pyrimethamine (SP) on the pharmacokinetic properties of each drug as a drug-drug interaction study to support the development of a fixed-dose combination therapy. A single-dose, open-label, crossover clinical trial was conducted in healthy adult Indian male volunteers (18 to 45 years, = 13) who received a single dose of AE or SP or a combination dose of AE and SP.

Single Ascending Dose Safety and Pharmacokinetics of CDRI-97/78: First-in-Human Study of a Novel Antimalarial Drug.

Background. CDRI 97/78 has shown efficacy in animal models of falciparum malaria. The present study is the first in-human phase I trial in healthy volunteers.

Predictive value of routine hematological and biochemical parameters on 30-day fatality in acute stroke.

Objective: This prospective study was planned to study the prognostic value of routine clinical, hematological and biochemical parameters, including platelet aggregation in patients of acute stroke, on fatality occurring during the first 30 days.

Material And Methods: In this study 116 consecutive patients (77 males and 39 females) of stroke (within 72 hours of onset) were included. After clinical evaluation and neuroimaging, blood investigations, hemoglobin, total leukocyte count, platelet count, platelet aggregation, erythrocyte sedimentation rate (ESR), blood sugar, urea, creatinine, sodium, potassium, serum cholesterol, serum bilirubin, aspartate aminotransferase (SGOT), alanine aminotransferase (SGPT), albumin, and globulin estimations were performed.

DOSE RESPONSE RELATIONSHIP OF NEUROMUSCULAR BLOCKADE, INTUBATION CONDITIONS AND CARDIOVASCULAR CHANGES WITH CHANDONIUM IODIDE.

One hundred and forty ASA physical status I and II patients undergoing general or gynaecological surgery were the subjects of this study. Patients were randomly assigned into five groups receiving 100, 150, 180, 200 and 250 µg/kg I.V.

Serum lipids and stroke.

Serum lipids and lipoproteins are strongly related to coronary atherosclerosis but their association with cerebrovascular atherosclerosis is far less clear and consistent, though lipid levels have been related to carotid artery atherosclerosis, in anumber of studies having angiographic or ultrasonographic evidences of atheromas of common carotid bifurcation and internal carotid artery. In these studies there appears to be an impressive correlation of increased low density lipoprotein (LDL) and reduced high density lipoprotein (HDL) to the atherosclerosis. Lipoprotein (a), Apoproteins (apo B and apo AI), and HDL sub fractions (HDL2 and HDL3) are emerging better indicators of cranial atherosclerosis than conventional serum lipid levels.