An improved methodology for estimating critical power from mean maximal power output data.

The aim of this study was to determine if Critical Power (CP) and W' can be estimated from mean maximal power output (MMP) data collected in cycling races. Data were collected from 13 under 23 professional cyclists (mean ± SD; age, 19.5 ± 1.

Optimizing adherence to allopurinol for gout: patients' perspectives.

Aims: Poor adherence to allopurinol among people with gout contributes to suboptimal gout management. This study sought to understand the facilitators and barriers to allopurinol adherence across the three stages of medication adherence, and patient perspectives on strategies to improve adherence, including self-monitoring urate concentration.

Methods: Semi-structured interviews were conducted with 26 people with gout, previously or currently taking allopurinol.

Predictors of cycling performance success: Traditional approaches and a novel method to assess performance capacity in U23 road cyclists.

Objectives: This study aimed to investigate predictors of cycling performance in U23 cyclists by comparing traditional approaches to a novel method - the compound score. Thirty male U23 cyclists (N = 30, age 20.1 ± 1.

The Relationship between Physiological Characteristics and Durability in Male Professional Cyclists.

Purpose: This study aimed to determine if durability can be predicted from laboratory measures in a professional cycling population.

Methods: Data were collected from 10 professional cyclists (age = 19.2 ± 0.

The relationship between training characteristics and durability in professional cyclists across a competitive season.

This study investigated the influence of training characteristics on the fatigued power profile in professional cyclists. Data was collected from 30 under 23 professional cyclists (age: 20.1 ± 1.

Power profiling and the power-duration relationship in cycling: a narrative review.

Emerging trends in technological innovations, data analysis and practical applications have facilitated the measurement of cycling power output in the field, leading to improvements in training prescription, performance testing and race analysis. This review aimed to critically reflect on power profiling strategies in association with the power-duration relationship in cycling, to provide an updated view for applied researchers and practitioners. The authors elaborate on measuring power output followed by an outline of the methodological approaches to power profiling.

Power Profiling, Workload Characteristics, and Race Performance of U23 and Professional Cyclists During the Multistage Race Tour of the Alps.

Purpose: The aim of this study was to compare the power profile, internal and external workloads, and racing performance between U23 and professional cyclists and between varying rider types across 2 editions of a professional multistage race.

Methods: Nine U23 cyclists from a Union Cycliste Internationale "Continental Team" (age 20.8 [0.

Power Profiling in U23 Professional Cyclists During a Competitive Season.

Purpose: The aim of this study was to investigate changes in the power profile of U23 professional cyclists during a competitive season based on maximal mean power output (MMP) and derived critical power (CP) and work capacity above CP (W') obtained during training and racing.

Methods: A total of 13 highly trained U23 professional cyclists (age = 21.1 [1.

Training Characteristics and Power Profile of Professional U23 Cyclists throughout a Competitive Season.

Background: The purpose of this study was to investigate differences in the power profile derived from training and racing, the training characteristics across a competitive season and the relationships between training and power profile in U23 professional cyclists.

Methods: Thirty male U23 professional cyclists (age, 20.0 ± 1.

Use of anti-platelet-endothelial cell adhesion molecule-1 antibody in the control of disease progression in established collagen-induced arthritis in DBA/1J mice.

Platelet-endothelial cell adhesion molecule-1 (PECAM-1) is expressed on the membrane of leukocytes and vascular endothelial cells. PECAM-1 has been shown to play an important role in the process of leukocyte transmigration in various animal models of acute inflammation. We investigated the role of PECAM-1 in the progression of arthritis by systemically administering anti-murine PECAM-1 monoclonal antibody, 2H8, to DBA/1J mice with collagen-induced arthritis (CIA).

Beagle 2: a proposed exobiology lander for ESA's 2003 Mars Express mission.

The aim of the proposed Beagle 2 small lander for ESA's 2003 Mars Express mission is to search for organic material on and below the surface of Mars and to study the inorganic chemistry and mineralogy of the landing site. The lander will have a total mass of 60kg including entry, descent, and landing system. Experiments will be deployed on the surface using a robotic arm.

Homophilic PECAM-1(CD31) interactions prevent endothelial cell apoptosis but do not support cell spreading or migration.

PECAM-1 (CD31) is a highly abundant cell surface glycoprotein expressed on haemopoietic and endothelial cells. As well as mediating homophilic (PECAM-1/PECAM-1) adhesion, PECAM-1 can also bind the integrin alphavbeta3. Both PECAM-1 and alphavbeta3 have been shown to have roles in regulating angiogenesis, endothelial tube formation and in the case of alphavbeta3, endothelial cell apoptosis.

Association between receptor density, cellular activation, and transformation of adhesive behavior of flowing lymphocytes binding to VCAM-1.

We investigated the ability of purified vascular cell adhesion molecule-1 (VCAM-1), adsorbed on plastic, to capture and immobilize flowing lymphocytes, and the dependence of adhesive behavior on activation of the counter-receptor, alpha 4 beta 1 integrin. This integrin/immunoglobulin interaction bound lymphocytes at a wall shear stress at which the beta 2-integrin family has previously been found ineffective (> 0.1 Pa), and whereas lymphocytes rolled on lower concentrations of VCAM-1 (10 micrograms/ml), they were stationary at high concentrations (100 micrograms/ml).

The X-Ray CCDs Developed for the Joint European X-Ray Telescope.

The charge coupled devices (CCDs) developed for the Joint European X-ray Telescope (JET-X) are described in detail. A history of the development program and device performance is given. We present results from a comprehensive study to characterize the x-ray response of the flight model focal plane detectors.

Mapping the homotypic binding sites in CD31 and the role of CD31 adhesion in the formation of interendothelial cell contacts.

CD31 is a member of the immunoglobulin superfamily consisting of six Ig-related domains. It is constitutively expressed by platelets, monocytes, and some lymphocytes, but at tenfold higher levels on vascular endothelial cells. CD31 has both homotypic and heterotypic adhesive properties.

Recognition of cryptic sites in human and mouse laminins by rat osteoclasts is mediated by beta 3 and beta 1 integrins.

Laminins may be encountered by osteoclasts and their precursors in basement membranes when they migrate from periosteal vasculature during skeletal development and in pathological situations. We have examined the recognition by osteoclasts of intact laminins and their proteolytic derivatives, and analysed the mechanism of adhesion. Rat osteoclasts fail to bind intact mouse Engelbreth-Holm-Swarm (EHS) laminin (3% adhesion relative to adhesion to foetal calf serum proteins) and bind only weakly to native human placental laminin (13%) or human merosin (9%).

Studies of lymphocyte transendothelial migration: analysis of migrated cell phenotypes with regard to CD31 (PECAM-1), CD45RA and CD45RO.

CD31 is a 130,000 MW cell-surface glycoprotein expressed on endothelial cells, polymorphonuclear leucocytes, monocytes and about 50% of peripheral blood lymphocytes, and it has been proposed that it plays a role in transendothelial migration. If it is involved in endothelial transmigration of lymphocytes then the proportion of CD31+ cells should be increased in the lymphocyte population which has crossed an endothelial monolayer. This was tested using two endothelial types, namely human umbilical vein endothelial cells (HUVEC) and rat high endothelial venule (RHEV) cells.