Publications by authors named "Spiros D Chondropoulos"
Background: Despite advances in the treatment of oncology patients, therapy-related side effects may lead to premature morbidity. Inflammatory activation that has been linked to cardiovascular disease is crucial for the pathogenesis of both Hodgkin (HL) and non-Hodgkin lymphoma (NHL).
Objectives: The purpose of this study was to assess the vascular effects of chemotherapy in patients with HL and NHL by positron emission tomography/computed tomography with 18-fluorodeoxyglucose (18-FDG PET/CT) and to investigate interactions with systemic inflammation as assessed by circulating inflammatory markers.
Article Synopsis
- The study investigated the relationship between lymphoma severity and cardiovascular health, specifically looking at arterial inflammation through FDG uptake in patients with active Hodgkin's and non-Hodgkin's lymphoma.
- Sixty-two chemotherapy-naïve patients were compared to previously treated lymphoma patients to assess metabolic tumor volume and glycolysis associated with arterial fluoride uptake.
- Results showed significant correlations between disease severity and arterial inflammation, with higher FDG uptake in active lymphoma patients compared to controls, particularly in advanced stages of the disease.